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Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs
OBJECTIVE: Previous studies suggest that daily music listening can aid stroke recovery, but little is known about the stimulus‐dependent and neural mechanisms driving this effect. Building on neuroimaging evidence that vocal music engages extensive and bilateral networks in the brain, we sought to d...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664275/ https://www.ncbi.nlm.nih.gov/pubmed/33022148 http://dx.doi.org/10.1002/acn3.51217 |
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author | Sihvonen, Aleksi J. Leo, Vera Ripollés, Pablo Lehtovaara, Terhi Ylönen, Aki Rajanaro, Pekka Laitinen, Sari Forsblom, Anita Saunavaara, Jani Autti, Taina Laine, Matti Rodríguez‐Fornells, Antoni Tervaniemi, Mari Soinila, Seppo Särkämö, Teppo |
author_facet | Sihvonen, Aleksi J. Leo, Vera Ripollés, Pablo Lehtovaara, Terhi Ylönen, Aki Rajanaro, Pekka Laitinen, Sari Forsblom, Anita Saunavaara, Jani Autti, Taina Laine, Matti Rodríguez‐Fornells, Antoni Tervaniemi, Mari Soinila, Seppo Särkämö, Teppo |
author_sort | Sihvonen, Aleksi J. |
collection | PubMed |
description | OBJECTIVE: Previous studies suggest that daily music listening can aid stroke recovery, but little is known about the stimulus‐dependent and neural mechanisms driving this effect. Building on neuroimaging evidence that vocal music engages extensive and bilateral networks in the brain, we sought to determine if it would be more effective for enhancing cognitive and language recovery and neuroplasticity than instrumental music or speech after stroke. METHODS: Using data pooled from two single‐blind randomized controlled trials in stroke patients (N = 83), we compared the effects of daily listening to self‐selected vocal music, instrumental music, and audiobooks during the first 3 poststroke months. Outcome measures comprised neuropsychological tests of verbal memory (primary outcome), language, and attention and a mood questionnaire performed at acute, 3‐month, and 6‐month stages and structural and functional MRI at acute and 6‐month stages. RESULTS: Listening to vocal music enhanced verbal memory recovery more than instrumental music or audiobooks and language recovery more than audiobooks, especially in aphasic patients. Voxel‐based morphometry and resting‐state and task‐based fMRI results showed that vocal music listening selectively increased gray matter volume in left temporal areas and functional connectivity in the default mode network. INTERPRETATION: Vocal music listening is an effective and easily applicable tool to support cognitive recovery after stroke as well as to enhance early language recovery in aphasia. The rehabilitative effects of vocal music are driven by both structural and functional plasticity changes in temporoparietal networks crucial for emotional processing, language, and memory. |
format | Online Article Text |
id | pubmed-7664275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76642752020-11-17 Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs Sihvonen, Aleksi J. Leo, Vera Ripollés, Pablo Lehtovaara, Terhi Ylönen, Aki Rajanaro, Pekka Laitinen, Sari Forsblom, Anita Saunavaara, Jani Autti, Taina Laine, Matti Rodríguez‐Fornells, Antoni Tervaniemi, Mari Soinila, Seppo Särkämö, Teppo Ann Clin Transl Neurol Research Articles OBJECTIVE: Previous studies suggest that daily music listening can aid stroke recovery, but little is known about the stimulus‐dependent and neural mechanisms driving this effect. Building on neuroimaging evidence that vocal music engages extensive and bilateral networks in the brain, we sought to determine if it would be more effective for enhancing cognitive and language recovery and neuroplasticity than instrumental music or speech after stroke. METHODS: Using data pooled from two single‐blind randomized controlled trials in stroke patients (N = 83), we compared the effects of daily listening to self‐selected vocal music, instrumental music, and audiobooks during the first 3 poststroke months. Outcome measures comprised neuropsychological tests of verbal memory (primary outcome), language, and attention and a mood questionnaire performed at acute, 3‐month, and 6‐month stages and structural and functional MRI at acute and 6‐month stages. RESULTS: Listening to vocal music enhanced verbal memory recovery more than instrumental music or audiobooks and language recovery more than audiobooks, especially in aphasic patients. Voxel‐based morphometry and resting‐state and task‐based fMRI results showed that vocal music listening selectively increased gray matter volume in left temporal areas and functional connectivity in the default mode network. INTERPRETATION: Vocal music listening is an effective and easily applicable tool to support cognitive recovery after stroke as well as to enhance early language recovery in aphasia. The rehabilitative effects of vocal music are driven by both structural and functional plasticity changes in temporoparietal networks crucial for emotional processing, language, and memory. John Wiley and Sons Inc. 2020-10-06 /pmc/articles/PMC7664275/ /pubmed/33022148 http://dx.doi.org/10.1002/acn3.51217 Text en © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Sihvonen, Aleksi J. Leo, Vera Ripollés, Pablo Lehtovaara, Terhi Ylönen, Aki Rajanaro, Pekka Laitinen, Sari Forsblom, Anita Saunavaara, Jani Autti, Taina Laine, Matti Rodríguez‐Fornells, Antoni Tervaniemi, Mari Soinila, Seppo Särkämö, Teppo Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs |
title | Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs |
title_full | Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs |
title_fullStr | Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs |
title_full_unstemmed | Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs |
title_short | Vocal music enhances memory and language recovery after stroke: pooled results from two RCTs |
title_sort | vocal music enhances memory and language recovery after stroke: pooled results from two rcts |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664275/ https://www.ncbi.nlm.nih.gov/pubmed/33022148 http://dx.doi.org/10.1002/acn3.51217 |
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