SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

Isolated reports of new-onset diabetes in individuals with COVID-19 have led to the hypothesis that SARS-CoV-2 is directly cytotoxic to pancreatic islet β cells. This would require binding and entry of SARS-CoV-2 into β cells via co-expression of its canonical cell entry factors, angiotensin-convert...

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Detalles Bibliográficos
Autores principales: Coate, Katie C., Cha, Jeeyeon, Shrestha, Shristi, Wang, Wenliang, Gonçalves, Luciana Mateus, Almaça, Joana, Kapp, Meghan E., Fasolino, Maria, Morgan, Ashleigh, Dai, Chunhua, Saunders, Diane C., Bottino, Rita, Aramandla, Radhika, Jenkins, Regina, Stein, Roland, Kaestner, Klaus H., Vahedi, Golnaz, Brissova, Marcela, Powers, Alvin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Short Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664344/
https://www.ncbi.nlm.nih.gov/pubmed/33207245
http://dx.doi.org/10.1016/j.cmet.2020.11.006

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