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Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC

While cell fusion demonstrates an important pathway during tissue development and regeneration of distinct organs, this process can also contribute to pathophysiological phenotypes during tumor progression. Hybrid cell formation after heterofusion between cancer cells and various other cell types wi...

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Detalles Bibliográficos
Autores principales: Melzer, Catharina, von der Ohe, Juliane, Hass, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664391/
https://www.ncbi.nlm.nih.gov/pubmed/33172211
http://dx.doi.org/10.3390/ijms21218347
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author Melzer, Catharina
von der Ohe, Juliane
Hass, Ralf
author_facet Melzer, Catharina
von der Ohe, Juliane
Hass, Ralf
author_sort Melzer, Catharina
collection PubMed
description While cell fusion demonstrates an important pathway during tissue development and regeneration of distinct organs, this process can also contribute to pathophysiological phenotypes during tumor progression. Hybrid cell formation after heterofusion between cancer cells and various other cell types within the tumor microenvironment is observed in vitro and in vivo. In particular, mesenchymal stroma/stem-like cells (MSC) perform diverse levels of communication with cancer cells by exhibiting anti- and pro-tumorigenic effects. During these cellular interactions, MSC can eventually fuse with cancer cells. Thereby, the newly generated disparate hybrid populations display aneuploidy associated with chromosomal instability. Based upon a subsequent post-hybrid selection process (PHSP), fused cancer cells can undergo apoptosis/necroptosis, senescence, dormancy, or a proliferative state by acquisition of new properties. Consequently, PHSP-surviving hybrid cancer cells demonstrate altered functionalities within the tumor tissue. This is accompanied by changes in therapeutic responsiveness and a different metastatic behavior. Accordingly, enhanced tumor plasticity interferes with successful therapeutic interventions and aggravates patient prognoses. The present review article focusses on fusion of MSC with different human cancer cells, in particular breast cancer populations and resulting characteristics of various cancer hybrid cells. Moreover, some mechanisms of cancer cell fusion are discussed together with multiple PHSP pathways.
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spelling pubmed-76643912020-11-14 Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC Melzer, Catharina von der Ohe, Juliane Hass, Ralf Int J Mol Sci Review While cell fusion demonstrates an important pathway during tissue development and regeneration of distinct organs, this process can also contribute to pathophysiological phenotypes during tumor progression. Hybrid cell formation after heterofusion between cancer cells and various other cell types within the tumor microenvironment is observed in vitro and in vivo. In particular, mesenchymal stroma/stem-like cells (MSC) perform diverse levels of communication with cancer cells by exhibiting anti- and pro-tumorigenic effects. During these cellular interactions, MSC can eventually fuse with cancer cells. Thereby, the newly generated disparate hybrid populations display aneuploidy associated with chromosomal instability. Based upon a subsequent post-hybrid selection process (PHSP), fused cancer cells can undergo apoptosis/necroptosis, senescence, dormancy, or a proliferative state by acquisition of new properties. Consequently, PHSP-surviving hybrid cancer cells demonstrate altered functionalities within the tumor tissue. This is accompanied by changes in therapeutic responsiveness and a different metastatic behavior. Accordingly, enhanced tumor plasticity interferes with successful therapeutic interventions and aggravates patient prognoses. The present review article focusses on fusion of MSC with different human cancer cells, in particular breast cancer populations and resulting characteristics of various cancer hybrid cells. Moreover, some mechanisms of cancer cell fusion are discussed together with multiple PHSP pathways. MDPI 2020-11-06 /pmc/articles/PMC7664391/ /pubmed/33172211 http://dx.doi.org/10.3390/ijms21218347 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Melzer, Catharina
von der Ohe, Juliane
Hass, Ralf
Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
title Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
title_full Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
title_fullStr Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
title_full_unstemmed Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
title_short Altered Tumor Plasticity after Different Cancer Cell Fusions with MSC
title_sort altered tumor plasticity after different cancer cell fusions with msc
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664391/
https://www.ncbi.nlm.nih.gov/pubmed/33172211
http://dx.doi.org/10.3390/ijms21218347
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