Placental inflammasome signaling: Protection for mother and baby

The second trimester of pregnancy is traditionally viewed as an immunosuppressive state. Megli et al. (https://doi.org/10.1084/jem.20200649) change this paradigm, showing that midgestation induces inflammasome signaling in placental trophoblasts to promote fetal and maternal antimicrobial defense. T...

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Detalles Bibliográficos
Autores principales: Burgener, Sabrina Sofia, Schroder, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664510/
https://www.ncbi.nlm.nih.gov/pubmed/33175107
http://dx.doi.org/10.1084/jem.20201738
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author Burgener, Sabrina Sofia
Schroder, Kate
author_facet Burgener, Sabrina Sofia
Schroder, Kate
author_sort Burgener, Sabrina Sofia
collection PubMed
description The second trimester of pregnancy is traditionally viewed as an immunosuppressive state. Megli et al. (https://doi.org/10.1084/jem.20200649) change this paradigm, showing that midgestation induces inflammasome signaling in placental trophoblasts to promote fetal and maternal antimicrobial defense. The placenta is thus a dynamic immunological organ.
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spelling pubmed-76645102021-07-04 Placental inflammasome signaling: Protection for mother and baby Burgener, Sabrina Sofia Schroder, Kate J Exp Med Insights The second trimester of pregnancy is traditionally viewed as an immunosuppressive state. Megli et al. (https://doi.org/10.1084/jem.20200649) change this paradigm, showing that midgestation induces inflammasome signaling in placental trophoblasts to promote fetal and maternal antimicrobial defense. The placenta is thus a dynamic immunological organ. Rockefeller University Press 2020-11-11 /pmc/articles/PMC7664510/ /pubmed/33175107 http://dx.doi.org/10.1084/jem.20201738 Text en © 2020 Burgener and Schroder http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Burgener, Sabrina Sofia
Schroder, Kate
Placental inflammasome signaling: Protection for mother and baby
title Placental inflammasome signaling: Protection for mother and baby
title_full Placental inflammasome signaling: Protection for mother and baby
title_fullStr Placental inflammasome signaling: Protection for mother and baby
title_full_unstemmed Placental inflammasome signaling: Protection for mother and baby
title_short Placental inflammasome signaling: Protection for mother and baby
title_sort placental inflammasome signaling: protection for mother and baby
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664510/
https://www.ncbi.nlm.nih.gov/pubmed/33175107
http://dx.doi.org/10.1084/jem.20201738
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