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A nidovirus perspective on SARS-CoV-2

Two pandemics of respiratory distress diseases associated with zoonotic introductions of the species Severe acute respiratory syndrome-related coronavirus in the human population during 21st century raised unprecedented interest in coronavirus research and assigned it unseen urgency. The two viruses...

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Detalles Bibliográficos
Autores principales: Gulyaeva, Anastasia A., Gorbalenya, Alexander E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664520/
https://www.ncbi.nlm.nih.gov/pubmed/33413979
http://dx.doi.org/10.1016/j.bbrc.2020.11.015
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author Gulyaeva, Anastasia A.
Gorbalenya, Alexander E.
author_facet Gulyaeva, Anastasia A.
Gorbalenya, Alexander E.
author_sort Gulyaeva, Anastasia A.
collection PubMed
description Two pandemics of respiratory distress diseases associated with zoonotic introductions of the species Severe acute respiratory syndrome-related coronavirus in the human population during 21st century raised unprecedented interest in coronavirus research and assigned it unseen urgency. The two viruses responsible for the outbreaks, SARS-CoV and SARS-CoV-2, respectively, are in the spotlight, and SARS-CoV-2 is the focus of the current fast-paced research. Its foundation was laid down by studies of many corona- and related viruses that collectively form the vast order Nidovirales. Comparative genomics of nidoviruses played a key role in this advancement over more than 30 years. It facilitated the transfer of knowledge from characterized to newly identified viruses, including SARS-CoV and SARS-CoV-2, as well as contributed to the dissection of the nidovirus proteome and identification of patterns of variations between different taxonomic groups, from species to families. This review revisits selected cases of protein conservation and variation that define nidoviruses, illustrates the remarkable plasticity of the proteome during nidovirus adaptation, and asks questions at the interface of the proteome and processes that are vital for nidovirus reproduction and could inform the ongoing research of SARS-CoV-2.
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spelling pubmed-76645202020-11-16 A nidovirus perspective on SARS-CoV-2 Gulyaeva, Anastasia A. Gorbalenya, Alexander E. Biochem Biophys Res Commun Article Two pandemics of respiratory distress diseases associated with zoonotic introductions of the species Severe acute respiratory syndrome-related coronavirus in the human population during 21st century raised unprecedented interest in coronavirus research and assigned it unseen urgency. The two viruses responsible for the outbreaks, SARS-CoV and SARS-CoV-2, respectively, are in the spotlight, and SARS-CoV-2 is the focus of the current fast-paced research. Its foundation was laid down by studies of many corona- and related viruses that collectively form the vast order Nidovirales. Comparative genomics of nidoviruses played a key role in this advancement over more than 30 years. It facilitated the transfer of knowledge from characterized to newly identified viruses, including SARS-CoV and SARS-CoV-2, as well as contributed to the dissection of the nidovirus proteome and identification of patterns of variations between different taxonomic groups, from species to families. This review revisits selected cases of protein conservation and variation that define nidoviruses, illustrates the remarkable plasticity of the proteome during nidovirus adaptation, and asks questions at the interface of the proteome and processes that are vital for nidovirus reproduction and could inform the ongoing research of SARS-CoV-2. The Authors. Published by Elsevier Inc. 2021-01-29 2020-11-13 /pmc/articles/PMC7664520/ /pubmed/33413979 http://dx.doi.org/10.1016/j.bbrc.2020.11.015 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Gulyaeva, Anastasia A.
Gorbalenya, Alexander E.
A nidovirus perspective on SARS-CoV-2
title A nidovirus perspective on SARS-CoV-2
title_full A nidovirus perspective on SARS-CoV-2
title_fullStr A nidovirus perspective on SARS-CoV-2
title_full_unstemmed A nidovirus perspective on SARS-CoV-2
title_short A nidovirus perspective on SARS-CoV-2
title_sort nidovirus perspective on sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664520/
https://www.ncbi.nlm.nih.gov/pubmed/33413979
http://dx.doi.org/10.1016/j.bbrc.2020.11.015
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