Cargando…

In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors

Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1H-indol-3-yl)methyl)-1,3,4-oxadiazol-2-yl)thio]-N-(thiazol/benzothiazol-2-yl)acetamides (2a–i) were designed and synthesized as EGFR and COX-2 inh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sever, Belgin, Altıntop, Mehlika Dilek, Özdemir, Ahmet, Akalın Çiftçi, Gülşen, Ellakwa, Doha E., Tateishi, Hiroshi, Radwan, Mohamed O., Ibrahim, Mahmoud A. A., Otsuka, Masami, Fujita, Mikako, Ciftci, Halil I., Ali, Taha F. S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664637/ https://www.ncbi.nlm.nih.gov/pubmed/33171861 http://dx.doi.org/10.3390/molecules25215190

Ejemplares similares

Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2018)

A New Series of Indeno[1,2-c]pyrazoles as EGFR TK Inhibitors for NSCLC Therapy
por: Özdemir, Ahmet, et al.
Publicado: (2022)

Design, Synthesis, and Biological Evaluation of Novel 1,3,4-Thiadiazole Derivatives as Potential Antitumor Agents against Chronic Myelogenous Leukemia: Striking Effect of Nitrothiazole Moiety
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2017)

Discovery of Small Molecule COX-1 and Akt Inhibitors as Anti-NSCLC Agents Endowed with Anti-Inflammatory Action
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2023)

Synthesis and Evaluation of New Benzodioxole- Based Thiosemicarbazone Derivatives as Potential Antitumor Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2016)

Synthesis and Evaluation of New Pyrazoline Derivatives as Potential Anticancer Agents
por: Karabacak, Muhammed, et al.
Publicado: (2015)

Design, Synthesis, and Evaluation of a New Series of Hydrazones as Small-Molecule Akt Inhibitors for NSCLC Therapy
por: Erdönmez, Burak, et al.
Publicado: (2023)

EGFR-Targeted Pentacyclic Triterpene Analogues for Glioma Therapy
por: Ciftci, Halil I., et al.
Publicado: (2021)

Synthesis and Evaluation of New Oxadiazole, Thiadiazole, and Triazole Derivatives as Potential Anticancer Agents Targeting MMP-9
por: Özdemir, Ahmet, et al.
Publicado: (2017)

Design, Synthesis, and Neuroprotective Effects of a Series of Pyrazolines against 6-Hydroxydopamine-Induced Oxidative Stress
por: Özdemir, Ahmet, et al.
Publicado: (2018)

Antiproliferative S-Trityl-l-Cysteine -Derived Compounds as SIRT2 Inhibitors: Repurposing and Solubility Enhancement
por: Radwan, Mohamed O., et al.
Publicado: (2019)

Pyrazole Incorporated New Thiosemicarbazones: Design, Synthesis and Investigation of DPP-4 Inhibitory Effects
por: Sever, Belgin, et al.
Publicado: (2020)

Comprehensive Research on Past and Future Therapeutic Strategies Devoted to Treatment of Amyotrophic Lateral Sclerosis
por: Sever, Belgin, et al.
Publicado: (2022)

A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity
por: Özdemir, Ahmet, et al.
Publicado: (2017)

Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity
por: I. Ciftci, Halil, et al.
Publicado: (2019)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2016)

In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

Identification of New L-Heptanoylphosphatidyl Inositol Pentakisphosphate Derivatives Targeting the Interaction with HIV-1 Gag by Molecular Modelling Studies
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

Design, Synthesis, and Evaluation of a New Series of 2-Pyrazolines as Potential Antileukemic Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2023)

In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity
por: Ali, Taha F. S., et al.
Publicado: (2022)

Structural Characterization of TRAF6 N-Terminal for Therapeutic Uses and Computational Studies on New Derivatives
por: Guven, Omur, et al.
Publicado: (2023)

Introduction of H2C2‐type zinc‐binding residues into HIV‐2 Vpr increases its expression level
por: Koga, Ryoko, et al.
Publicado: (2017)

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives
por: Glomb, Teresa, et al.
Publicado: (2021)

5-Phenyl-1,3,4-oxadiazol-2-amine
por: Song, Man-Man, et al.
Publicado: (2012)

Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole
por: Glomb, Teresa, et al.
Publicado: (2018)

1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction
por: Wang, Qian, et al.
Publicado: (2019)

Electrophilic activation of nitroalkanes in efficient synthesis of 1,3,4-oxadiazoles
por: Aksenov, Alexander V., et al.
Publicado: (2019)

Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives
por: Stecoza, Camelia Elena, et al.
Publicado: (2021)

A clue to unprecedented strategy to HIV eradication: “Lock-in and apoptosis”
por: Tateishi, Hiroshi, et al.
Publicado: (2017)

2-[3,4-Dibutoxy-5-(5-phenyl-1,3,4-oxadiazol-2-yl)-2-thienyl]-5-phenyl-1,3,4-oxadiazole
por: Li, Hai-lin, et al.
Publicado: (2008)

Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-d]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors
por: Szczukowski, Łukasz, et al.
Publicado: (2020)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review
por: Wang, Jing-Jing, et al.
Publicado: (2022)

Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
por: Özdemir, Ahmet, et al.
Publicado: (2015)

Synthesis and in Vitro Evaluation of New Nitro-Substituted Thiazolyl Hydrazone Derivatives as Anticandidal and Anticancer Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2014)

2-Phenyl-5-(p-tolyl)-1,3,4-oxadiazole
por: Cordes, David B., et al.
Publicado: (2011)

Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
por: Bhat, KI, et al.
Publicado: (2011)

Trifluoromethylpyridine 1,3,4-Oxadiazole Derivatives: Emerging Scaffolds as Bacterial Agents
por: Yu, Gang, et al.
Publicado: (2021)

Antileukemic Activity of Twig Components of Caucasian Beech in Turkey
por: Shida, Wataru, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_s1ep6pf2akkfo4rsjanrdcqa9g