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A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles

Lipidic vehicles are novel industrial products, utilized as components for pharmaceutical, cosmeceutical and nutraceutical formulations. The present study concerns a newly invented method to produce lipidic vehicles in the nanoscale that is simple, nontoxic, versatile, time-efficient, low-cost and e...

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Detalles Bibliográficos
Autores principales: Naziris, Nikolaos, Pippa, Natassa, Demetzos, Costas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664659/
https://www.ncbi.nlm.nih.gov/pubmed/33171678
http://dx.doi.org/10.3390/ma13215035
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author Naziris, Nikolaos
Pippa, Natassa
Demetzos, Costas
author_facet Naziris, Nikolaos
Pippa, Natassa
Demetzos, Costas
author_sort Naziris, Nikolaos
collection PubMed
description Lipidic vehicles are novel industrial products, utilized as components for pharmaceutical, cosmeceutical and nutraceutical formulations. The present study concerns a newly invented method to produce lipidic vehicles in the nanoscale that is simple, nontoxic, versatile, time-efficient, low-cost and easy to scale up. The process is a modification of the heating method (MHM) and comprises (i) providing a mixture of an amphiphilic lipid and a charged lipid and/or a fluidity regulator in a liquid medium composed of water and a liquid polyol, (ii) stirring and heating the mixture in two heating steps, wherein the temperature of the second step is higher than the temperature of the first step and (iii) allowing the mixture to cool down to room temperature. The process leads to the self-assembly of nanoparticles of small size and good homogeneity, compared with conventional approaches that require additional size reduction steps. In addition, the incorporation of bioactive molecules, such as drugs, inside the nanoparticles is possible, while lyophilization of the products provides long-term stability. Most importantly, the absence of toxic solvents and the simplicity guarantee the safety and scalability of the process, distinguishing it from most prior art processes to produce lipidic vehicles.
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spelling pubmed-76646592020-11-14 A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles Naziris, Nikolaos Pippa, Natassa Demetzos, Costas Materials (Basel) Article Lipidic vehicles are novel industrial products, utilized as components for pharmaceutical, cosmeceutical and nutraceutical formulations. The present study concerns a newly invented method to produce lipidic vehicles in the nanoscale that is simple, nontoxic, versatile, time-efficient, low-cost and easy to scale up. The process is a modification of the heating method (MHM) and comprises (i) providing a mixture of an amphiphilic lipid and a charged lipid and/or a fluidity regulator in a liquid medium composed of water and a liquid polyol, (ii) stirring and heating the mixture in two heating steps, wherein the temperature of the second step is higher than the temperature of the first step and (iii) allowing the mixture to cool down to room temperature. The process leads to the self-assembly of nanoparticles of small size and good homogeneity, compared with conventional approaches that require additional size reduction steps. In addition, the incorporation of bioactive molecules, such as drugs, inside the nanoparticles is possible, while lyophilization of the products provides long-term stability. Most importantly, the absence of toxic solvents and the simplicity guarantee the safety and scalability of the process, distinguishing it from most prior art processes to produce lipidic vehicles. MDPI 2020-11-08 /pmc/articles/PMC7664659/ /pubmed/33171678 http://dx.doi.org/10.3390/ma13215035 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Naziris, Nikolaos
Pippa, Natassa
Demetzos, Costas
A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles
title A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles
title_full A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles
title_fullStr A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles
title_full_unstemmed A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles
title_short A Novel, Nontoxic and Scalable Process to Produce Lipidic Vehicles
title_sort novel, nontoxic and scalable process to produce lipidic vehicles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664659/
https://www.ncbi.nlm.nih.gov/pubmed/33171678
http://dx.doi.org/10.3390/ma13215035
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