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A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes

Sphingosine kinases (SK) catalyze the phosphorylation of sphingosine to generate sphingosine-1-phosphate. Two isoforms of SK (SK1 and SK2) exist in mammals. Previously, we showed the beneficial effects of SK2 inhibition, using ABC294640, in a psoriasis mouse model. However, ABC294640 also induces th...

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Detalles Bibliográficos
Autores principales:	Shin, Sun-Hye, Kim, Hee-Yeon, Yoon, Hee-Soo, Park, Woo-Jae, Adams, David R., Pyne, Nigel J., Pyne, Susan, Park, Joo-Won
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664669/ https://www.ncbi.nlm.nih.gov/pubmed/33171607 http://dx.doi.org/10.3390/ijms21218371

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