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Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study

Background: Results of studies regarding the potential link between acid suppressant use and dementia risk are inconsistent. This study aimed to evaluate the association of cumulative exposure to histamine 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) with dementia risk in an Asia...

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Autores principales: Chen, Liang-Yu, Lin, Huey-Juan, Wu, Wen-Tung, Chen, Yong-Chen, Chen, Cheng-Li, Kao, Jing, You, San-Lin, Chou, Yu-Ching, Sun, Chien-An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664895/
https://www.ncbi.nlm.nih.gov/pubmed/33182362
http://dx.doi.org/10.3390/ijerph17218271
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author Chen, Liang-Yu
Lin, Huey-Juan
Wu, Wen-Tung
Chen, Yong-Chen
Chen, Cheng-Li
Kao, Jing
You, San-Lin
Chou, Yu-Ching
Sun, Chien-An
author_facet Chen, Liang-Yu
Lin, Huey-Juan
Wu, Wen-Tung
Chen, Yong-Chen
Chen, Cheng-Li
Kao, Jing
You, San-Lin
Chou, Yu-Ching
Sun, Chien-An
author_sort Chen, Liang-Yu
collection PubMed
description Background: Results of studies regarding the potential link between acid suppressant use and dementia risk are inconsistent. This study aimed to evaluate the association of cumulative exposure to histamine 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) with dementia risk in an Asian older cohort aged ≥65 years. Methods: Patients initiating H2RA (the H2RA user cohort, n = 21,449) or PPI (the PPI user cohort, n = 6584) and those without prescription for H2RA (the H2RA non-user cohort, n = 21,449) or PPI (the PPI non-user cohort, n = 6584) between 1 January 2000 and 31 December 2005 without a prior history of dementia were identified from Taiwan’s National Health Insurance Research Database (NHIRD). The outcome of interest was all-cause dementia. Patients’ exposure to H2RAs or PPIs was followed-up from dates of initial prescription to the earliest outcome of incident dementia, death, or the end of 2013. Potential associations between acid suppressant use and dementia risk were analyzed using time-dependent Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After mutual adjustment for H2RA and PPI use and other potential confounders, patients with H2RA use had significantly higher risk of developing dementia as compared to those not treated with H2RAs (adjusted HR, 1.84; 95% CI, 1.49–2.20). Likewise, PPI users had significantly elevated risk of dementia compared to PPI non-users (adjusted HR, 1.42; 95% CI, 1.07–1.84). Conclusions: Our results indicate that exposures to H2RAs and PPIs are associated with increased dementia risk.
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spelling pubmed-76648952020-11-14 Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study Chen, Liang-Yu Lin, Huey-Juan Wu, Wen-Tung Chen, Yong-Chen Chen, Cheng-Li Kao, Jing You, San-Lin Chou, Yu-Ching Sun, Chien-An Int J Environ Res Public Health Article Background: Results of studies regarding the potential link between acid suppressant use and dementia risk are inconsistent. This study aimed to evaluate the association of cumulative exposure to histamine 2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) with dementia risk in an Asian older cohort aged ≥65 years. Methods: Patients initiating H2RA (the H2RA user cohort, n = 21,449) or PPI (the PPI user cohort, n = 6584) and those without prescription for H2RA (the H2RA non-user cohort, n = 21,449) or PPI (the PPI non-user cohort, n = 6584) between 1 January 2000 and 31 December 2005 without a prior history of dementia were identified from Taiwan’s National Health Insurance Research Database (NHIRD). The outcome of interest was all-cause dementia. Patients’ exposure to H2RAs or PPIs was followed-up from dates of initial prescription to the earliest outcome of incident dementia, death, or the end of 2013. Potential associations between acid suppressant use and dementia risk were analyzed using time-dependent Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After mutual adjustment for H2RA and PPI use and other potential confounders, patients with H2RA use had significantly higher risk of developing dementia as compared to those not treated with H2RAs (adjusted HR, 1.84; 95% CI, 1.49–2.20). Likewise, PPI users had significantly elevated risk of dementia compared to PPI non-users (adjusted HR, 1.42; 95% CI, 1.07–1.84). Conclusions: Our results indicate that exposures to H2RAs and PPIs are associated with increased dementia risk. MDPI 2020-11-09 2020-11 /pmc/articles/PMC7664895/ /pubmed/33182362 http://dx.doi.org/10.3390/ijerph17218271 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Liang-Yu
Lin, Huey-Juan
Wu, Wen-Tung
Chen, Yong-Chen
Chen, Cheng-Li
Kao, Jing
You, San-Lin
Chou, Yu-Ching
Sun, Chien-An
Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study
title Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study
title_full Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study
title_fullStr Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study
title_full_unstemmed Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study
title_short Clinical Use of Acid Suppressants and Risk of Dementia in the Elderly: A Pharmaco-Epidemiological Cohort Study
title_sort clinical use of acid suppressants and risk of dementia in the elderly: a pharmaco-epidemiological cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7664895/
https://www.ncbi.nlm.nih.gov/pubmed/33182362
http://dx.doi.org/10.3390/ijerph17218271
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