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Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy
This study aimed to evaluate the potential of oral probiotics to eradicate vaginal GBS colonization during the third trimester of pregnancy. We screened 1058 women for GBS colonization at 33–37 gestational weeks using a combination of vaginal-to-rectal swab and culture-based methods. Women who teste...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665007/ https://www.ncbi.nlm.nih.gov/pubmed/33184437 http://dx.doi.org/10.1038/s41598-020-76896-4 |
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author | Farr, Alex Sustr, Valentina Kiss, Herbert Rosicky, Ingo Graf, Alexandra Makristathis, Athanasios Foessleitner, Philipp Petricevic, Ljubomir |
author_facet | Farr, Alex Sustr, Valentina Kiss, Herbert Rosicky, Ingo Graf, Alexandra Makristathis, Athanasios Foessleitner, Philipp Petricevic, Ljubomir |
author_sort | Farr, Alex |
collection | PubMed |
description | This study aimed to evaluate the potential of oral probiotics to eradicate vaginal GBS colonization during the third trimester of pregnancy. We screened 1058 women for GBS colonization at 33–37 gestational weeks using a combination of vaginal-to-rectal swab and culture-based methods. Women who tested GBS positive were randomized to either the verum group, receiving a dietary probiotic supplement of four viable strains of Lactobacillus twice-daily for 14 days, or to the placebo group. Women underwent follow-up smears, whereat GBS colonization upon follow-up was considered the primary endpoint. We found that 215 women (20.3%) were positive for GBS upon screening, of which 82 (38.1%) were eligible for study inclusion; 41 (50%) of these were randomized to the verum and placebo groups each. After treatment, 21/33 (63.6%) members of the verum group, and 21/27 (77.8%) of the placebo group were still GBS positive (p = 0.24). Four (9.8%) women in the verum group and one (2.4%) in the placebo group experienced preterm birth (p = 0.20); smokers showed significantly higher rates of preterm birth (p = 0.03). Hence, the findings did not support the hypothesis that oral probiotics can eradicate GBS during pregnancy, although we observed a trend toward reduced GBS persistence after probiotic intake. |
format | Online Article Text |
id | pubmed-7665007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76650072020-11-16 Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy Farr, Alex Sustr, Valentina Kiss, Herbert Rosicky, Ingo Graf, Alexandra Makristathis, Athanasios Foessleitner, Philipp Petricevic, Ljubomir Sci Rep Article This study aimed to evaluate the potential of oral probiotics to eradicate vaginal GBS colonization during the third trimester of pregnancy. We screened 1058 women for GBS colonization at 33–37 gestational weeks using a combination of vaginal-to-rectal swab and culture-based methods. Women who tested GBS positive were randomized to either the verum group, receiving a dietary probiotic supplement of four viable strains of Lactobacillus twice-daily for 14 days, or to the placebo group. Women underwent follow-up smears, whereat GBS colonization upon follow-up was considered the primary endpoint. We found that 215 women (20.3%) were positive for GBS upon screening, of which 82 (38.1%) were eligible for study inclusion; 41 (50%) of these were randomized to the verum and placebo groups each. After treatment, 21/33 (63.6%) members of the verum group, and 21/27 (77.8%) of the placebo group were still GBS positive (p = 0.24). Four (9.8%) women in the verum group and one (2.4%) in the placebo group experienced preterm birth (p = 0.20); smokers showed significantly higher rates of preterm birth (p = 0.03). Hence, the findings did not support the hypothesis that oral probiotics can eradicate GBS during pregnancy, although we observed a trend toward reduced GBS persistence after probiotic intake. Nature Publishing Group UK 2020-11-12 /pmc/articles/PMC7665007/ /pubmed/33184437 http://dx.doi.org/10.1038/s41598-020-76896-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Farr, Alex Sustr, Valentina Kiss, Herbert Rosicky, Ingo Graf, Alexandra Makristathis, Athanasios Foessleitner, Philipp Petricevic, Ljubomir Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy |
title | Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy |
title_full | Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy |
title_fullStr | Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy |
title_full_unstemmed | Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy |
title_short | Oral probiotics to reduce vaginal group B streptococcal colonization in late pregnancy |
title_sort | oral probiotics to reduce vaginal group b streptococcal colonization in late pregnancy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665007/ https://www.ncbi.nlm.nih.gov/pubmed/33184437 http://dx.doi.org/10.1038/s41598-020-76896-4 |
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