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Anti-apoptotic BCL-2 regulation by changes in dynamics of its long unstructured loop

BCL-2, a key protein in inhibiting apoptosis, has a 65-residue-long highly flexible loop domain (FLD) located on the opposite side of its ligand-binding groove. In vivo phosphorylation of the FLD enhances the affinity of BCL-2 for pro-apoptotic ligands, and consequently anti-apoptotic activity. Howe...

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Detalles Bibliográficos
Autores principales:	Lan, Yu-Jing, Yeh, Pei-Shan, Kao, Te-Yu, Lo, Yuan-Chao, Sue, Shih-Che, Chen, Yu-Wen, Hwang, Dennis W., Chiang, Yun-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665024/ https://www.ncbi.nlm.nih.gov/pubmed/33184407 http://dx.doi.org/10.1038/s42003-020-01390-6

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