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An Overview of the Role of Adipokines in Cardiometabolic Diseases
Obesity as an independent risk factor for cardiovascular diseases (CVDs) leads to an increase in morbidity, mortality, and a shortening of life span. The changes in heart structure and function as well as metabolic profile are caused by obese people, including those free of metabolic disorders. Obes...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665135/ https://www.ncbi.nlm.nih.gov/pubmed/33182462 http://dx.doi.org/10.3390/molecules25215218 |
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author | Farkhondeh, Tahereh Llorens, Silvia Pourbagher-Shahri, Ali Mohammad Ashrafizadeh, Milad Talebi, Marjan Shakibaei, Mehdi Samarghandian, Saeed |
author_facet | Farkhondeh, Tahereh Llorens, Silvia Pourbagher-Shahri, Ali Mohammad Ashrafizadeh, Milad Talebi, Marjan Shakibaei, Mehdi Samarghandian, Saeed |
author_sort | Farkhondeh, Tahereh |
collection | PubMed |
description | Obesity as an independent risk factor for cardiovascular diseases (CVDs) leads to an increase in morbidity, mortality, and a shortening of life span. The changes in heart structure and function as well as metabolic profile are caused by obese people, including those free of metabolic disorders. Obesity alters heart function structure and affects lipid and glucose metabolism, blood pressure, and increase inflammatory cytokines. Adipokines, specific cytokines of adipocytes, are involved in the progression of obesity and the associated co-morbidities. In the current study, we review the scientific evidence on the effects of obesity on CVDs, focusing on the changes in adipokines. Several adipokines have anti-inflammatory and cardioprotective effects comprising omentin, apelin, adiponectin, and secreted frizzled-related protein (Sfrp-5). Other adipokines have pro-inflammatory impacts on the cardiovascular system and obesity including leptin, tumor necrosis factor (TNF), retinol-binding protein4 (RBP-4), visfatin, resistin, and osteopontin. We found that obesity is associated with multiple CVDs, but can only occur in unhealthy metabolic patients. However, more studies should be designed to clarify the association between obesity, adipokine changes, and the occurrence of CVDs. |
format | Online Article Text |
id | pubmed-7665135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76651352020-11-14 An Overview of the Role of Adipokines in Cardiometabolic Diseases Farkhondeh, Tahereh Llorens, Silvia Pourbagher-Shahri, Ali Mohammad Ashrafizadeh, Milad Talebi, Marjan Shakibaei, Mehdi Samarghandian, Saeed Molecules Review Obesity as an independent risk factor for cardiovascular diseases (CVDs) leads to an increase in morbidity, mortality, and a shortening of life span. The changes in heart structure and function as well as metabolic profile are caused by obese people, including those free of metabolic disorders. Obesity alters heart function structure and affects lipid and glucose metabolism, blood pressure, and increase inflammatory cytokines. Adipokines, specific cytokines of adipocytes, are involved in the progression of obesity and the associated co-morbidities. In the current study, we review the scientific evidence on the effects of obesity on CVDs, focusing on the changes in adipokines. Several adipokines have anti-inflammatory and cardioprotective effects comprising omentin, apelin, adiponectin, and secreted frizzled-related protein (Sfrp-5). Other adipokines have pro-inflammatory impacts on the cardiovascular system and obesity including leptin, tumor necrosis factor (TNF), retinol-binding protein4 (RBP-4), visfatin, resistin, and osteopontin. We found that obesity is associated with multiple CVDs, but can only occur in unhealthy metabolic patients. However, more studies should be designed to clarify the association between obesity, adipokine changes, and the occurrence of CVDs. MDPI 2020-11-09 /pmc/articles/PMC7665135/ /pubmed/33182462 http://dx.doi.org/10.3390/molecules25215218 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Farkhondeh, Tahereh Llorens, Silvia Pourbagher-Shahri, Ali Mohammad Ashrafizadeh, Milad Talebi, Marjan Shakibaei, Mehdi Samarghandian, Saeed An Overview of the Role of Adipokines in Cardiometabolic Diseases |
title | An Overview of the Role of Adipokines in Cardiometabolic Diseases |
title_full | An Overview of the Role of Adipokines in Cardiometabolic Diseases |
title_fullStr | An Overview of the Role of Adipokines in Cardiometabolic Diseases |
title_full_unstemmed | An Overview of the Role of Adipokines in Cardiometabolic Diseases |
title_short | An Overview of the Role of Adipokines in Cardiometabolic Diseases |
title_sort | overview of the role of adipokines in cardiometabolic diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665135/ https://www.ncbi.nlm.nih.gov/pubmed/33182462 http://dx.doi.org/10.3390/molecules25215218 |
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