Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model

There is increasing evidence that inducing neuronal mitophagy can be used as a therapeutic intervention for Alzheimer’s disease. Here, we screen a library of 2024 FDA-approved drugs or drug candidates, revealing UMI-77 as an unexpected mitophagy activator. UMI-77 is an established BH3-mimetic for MC...

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Detalles Bibliográficos
Autores principales: Cen, Xufeng, Chen, Yanying, Xu, Xiaoyan, Wu, Ronghai, He, Fusheng, Zhao, Qingwei, Sun, Qiming, Yi, Cong, Wu, Jie, Najafov, Ayaz, Xia, Hongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665171/
https://www.ncbi.nlm.nih.gov/pubmed/33184293
http://dx.doi.org/10.1038/s41467-020-19547-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665171/
https://www.ncbi.nlm.nih.gov/pubmed/33184293
http://dx.doi.org/10.1038/s41467-020-19547-6

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