Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer

CD44v6, the CD44 isoform mostly involved in cancer cell migration and invasion, has been identified as a functional biomarker and therapeutic target in colon cancer stem cells. We here provide evidence that baseline CD44v6-positive CTC predict treatment failure in patients with metastatic colorectal...

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Autores principales: Nicolazzo, Chiara, Loreni, Flavia, Caponnetto, Salvatore, Magri, Valentina, Vestri, Anna Rita, Zamarchi, Rita, Gradilone, Angela, Facchinetti, Antonella, Rossi, Elisabetta, Cortesi, Enrico, Gazzaniga, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665234/
https://www.ncbi.nlm.nih.gov/pubmed/33227095
http://dx.doi.org/10.18632/oncotarget.27794
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author Nicolazzo, Chiara
Loreni, Flavia
Caponnetto, Salvatore
Magri, Valentina
Vestri, Anna Rita
Zamarchi, Rita
Gradilone, Angela
Facchinetti, Antonella
Rossi, Elisabetta
Cortesi, Enrico
Gazzaniga, Paola
author_facet Nicolazzo, Chiara
Loreni, Flavia
Caponnetto, Salvatore
Magri, Valentina
Vestri, Anna Rita
Zamarchi, Rita
Gradilone, Angela
Facchinetti, Antonella
Rossi, Elisabetta
Cortesi, Enrico
Gazzaniga, Paola
author_sort Nicolazzo, Chiara
collection PubMed
description CD44v6, the CD44 isoform mostly involved in cancer cell migration and invasion, has been identified as a functional biomarker and therapeutic target in colon cancer stem cells. We here provide evidence that baseline CD44v6-positive CTC predict treatment failure in patients with metastatic colorectal cancer undergoing first-line chemotherapy. We suggest that CD44v6-positive CTC can be used to early detect intrinsic drug resistance in this cancer type.
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spelling pubmed-76652342020-11-20 Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer Nicolazzo, Chiara Loreni, Flavia Caponnetto, Salvatore Magri, Valentina Vestri, Anna Rita Zamarchi, Rita Gradilone, Angela Facchinetti, Antonella Rossi, Elisabetta Cortesi, Enrico Gazzaniga, Paola Oncotarget Research Paper CD44v6, the CD44 isoform mostly involved in cancer cell migration and invasion, has been identified as a functional biomarker and therapeutic target in colon cancer stem cells. We here provide evidence that baseline CD44v6-positive CTC predict treatment failure in patients with metastatic colorectal cancer undergoing first-line chemotherapy. We suggest that CD44v6-positive CTC can be used to early detect intrinsic drug resistance in this cancer type. Impact Journals LLC 2020-11-10 /pmc/articles/PMC7665234/ /pubmed/33227095 http://dx.doi.org/10.18632/oncotarget.27794 Text en Copyright: © 2020 Nicolazzo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Nicolazzo, Chiara
Loreni, Flavia
Caponnetto, Salvatore
Magri, Valentina
Vestri, Anna Rita
Zamarchi, Rita
Gradilone, Angela
Facchinetti, Antonella
Rossi, Elisabetta
Cortesi, Enrico
Gazzaniga, Paola
Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer
title Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer
title_full Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer
title_fullStr Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer
title_full_unstemmed Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer
title_short Baseline CD44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer
title_sort baseline cd44v6-positive circulating tumor cells to predict first-line treatment failure in patients with metastatic colorectal cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665234/
https://www.ncbi.nlm.nih.gov/pubmed/33227095
http://dx.doi.org/10.18632/oncotarget.27794
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