In situ structural analysis of SARS-CoV-2 spike reveals flexibility mediated by three hinges

The spike protein (S) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is required for cell entry and is the primary focus for vaccine development. In this study, we combined cryo–electron tomography, subtomogram averaging, and molecular dynamics simulations to structurally analyze S...

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Detalles Bibliográficos
Autores principales: Turoňová, Beata, Sikora, Mateusz, Schürmann, Christoph, Hagen, Wim J. H., Welsch, Sonja, Blanc, Florian E. C., von Bülow, Sören, Gecht, Michael, Bagola, Katrin, Hörner, Cindy, van Zandbergen, Ger, Landry, Jonathan, de Azevedo, Nayara Trevisan Doimo, Mosalaganti, Shyamal, Schwarz, Andre, Covino, Roberto, Mühlebach, Michael D., Hummer, Gerhard, Krijnse Locker, Jacomine, Beck, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665311/
https://www.ncbi.nlm.nih.gov/pubmed/32817270
http://dx.doi.org/10.1126/science.abd5223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665311/
https://www.ncbi.nlm.nih.gov/pubmed/32817270
http://dx.doi.org/10.1126/science.abd5223

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