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Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response
We investigated feasibility and accuracy of an interferon-γ release assay (IGRA) for detection of T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whole blood IGRA accurately distinguished between convalescent and uninfected healthy blood donors with a predominantly...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665338/ https://www.ncbi.nlm.nih.gov/pubmed/33035306 http://dx.doi.org/10.1093/cid/ciaa1537 |
| _version_ | 1783609991688617984 |
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| author | Murugesan, Kanagavel Jagannathan, Prasanna Pham, Tho D Pandey, Suchitra Bonilla, Hector F Jacobson, Karen Parsonnet, Julie Andrews, Jason R Weiskopf, Daniela Sette, Alessandro Pinsky, Benjamin A Singh, Upinder Banaei, Niaz |
| author_facet | Murugesan, Kanagavel Jagannathan, Prasanna Pham, Tho D Pandey, Suchitra Bonilla, Hector F Jacobson, Karen Parsonnet, Julie Andrews, Jason R Weiskopf, Daniela Sette, Alessandro Pinsky, Benjamin A Singh, Upinder Banaei, Niaz |
| author_sort | Murugesan, Kanagavel |
| collection | PubMed |
| description | We investigated feasibility and accuracy of an interferon-γ release assay (IGRA) for detection of T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whole blood IGRA accurately distinguished between convalescent and uninfected healthy blood donors with a predominantly CD4(+) T-cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the coronavirus disease 2019 pandemic. |
| format | Online Article Text |
| id | pubmed-7665338 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-76653382020-11-16 Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response Murugesan, Kanagavel Jagannathan, Prasanna Pham, Tho D Pandey, Suchitra Bonilla, Hector F Jacobson, Karen Parsonnet, Julie Andrews, Jason R Weiskopf, Daniela Sette, Alessandro Pinsky, Benjamin A Singh, Upinder Banaei, Niaz Clin Infect Dis Online only Articles We investigated feasibility and accuracy of an interferon-γ release assay (IGRA) for detection of T-cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whole blood IGRA accurately distinguished between convalescent and uninfected healthy blood donors with a predominantly CD4(+) T-cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the coronavirus disease 2019 pandemic. Oxford University Press 2020-10-09 /pmc/articles/PMC7665338/ /pubmed/33035306 http://dx.doi.org/10.1093/cid/ciaa1537 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_modelThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) |
| spellingShingle | Online only Articles Murugesan, Kanagavel Jagannathan, Prasanna Pham, Tho D Pandey, Suchitra Bonilla, Hector F Jacobson, Karen Parsonnet, Julie Andrews, Jason R Weiskopf, Daniela Sette, Alessandro Pinsky, Benjamin A Singh, Upinder Banaei, Niaz Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response |
| title | Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response |
| title_full | Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response |
| title_fullStr | Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response |
| title_full_unstemmed | Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response |
| title_short | Interferon-γ Release Assay for Accurate Detection of Severe Acute Respiratory Syndrome Coronavirus 2 T-Cell Response |
| title_sort | interferon-γ release assay for accurate detection of severe acute respiratory syndrome coronavirus 2 t-cell response |
| topic | Online only Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665338/ https://www.ncbi.nlm.nih.gov/pubmed/33035306 http://dx.doi.org/10.1093/cid/ciaa1537 |
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