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The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association

The radiochemical analysis of plutonium activity in urine is the main method for indirect estimation of doses of internal exposure from plutonium incorporation in professional workers. It was previously shown that late-in-life acute diseases, particularly those that affect the liver, can promote acc...

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Autores principales: Suslova, Klara G., Efimov, Alexander V., Sokolova, Alexandra B., Napier, Bruce A., Miller, Scott C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665703/
https://www.ncbi.nlm.nih.gov/pubmed/33186401
http://dx.doi.org/10.1371/journal.pone.0242151
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author Suslova, Klara G.
Efimov, Alexander V.
Sokolova, Alexandra B.
Napier, Bruce A.
Miller, Scott C.
author_facet Suslova, Klara G.
Efimov, Alexander V.
Sokolova, Alexandra B.
Napier, Bruce A.
Miller, Scott C.
author_sort Suslova, Klara G.
collection PubMed
description The radiochemical analysis of plutonium activity in urine is the main method for indirect estimation of doses of internal exposure from plutonium incorporation in professional workers. It was previously shown that late-in-life acute diseases, particularly those that affect the liver, can promote accelerated rates of release of plutonium from the liver with enhanced excretion rates. This initial study examines the relationships of some chronic diseases on plutonium excretion as well as the terminal relative distribution of plutonium between the liver and skeleton. Fourteen cases from former workers at the Mayak Production Association (Mayak PA) who provided from 4–9 urine plutonium bioassays for plutonium, had an autopsy conducted after death, and had sufficient clinical records to document their health status were used in this study. Enhanced plutonium excretion was associated with more serious chronic diseases, including cardiovascular diseases and other diseases that involved the liver. These chronic diseases were also associated with relatively less plutonium found in the liver relative to the skeleton determined by analyses conducted after autopsy. These data further document health conditions that affect plutonium biokinetics and organ deposition and retention patterns and suggest that health status should be considered when conducting plutonium bioassays as these may alter subsequent dosimetry and risk models.
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spelling pubmed-76657032020-11-18 The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association Suslova, Klara G. Efimov, Alexander V. Sokolova, Alexandra B. Napier, Bruce A. Miller, Scott C. PLoS One Research Article The radiochemical analysis of plutonium activity in urine is the main method for indirect estimation of doses of internal exposure from plutonium incorporation in professional workers. It was previously shown that late-in-life acute diseases, particularly those that affect the liver, can promote accelerated rates of release of plutonium from the liver with enhanced excretion rates. This initial study examines the relationships of some chronic diseases on plutonium excretion as well as the terminal relative distribution of plutonium between the liver and skeleton. Fourteen cases from former workers at the Mayak Production Association (Mayak PA) who provided from 4–9 urine plutonium bioassays for plutonium, had an autopsy conducted after death, and had sufficient clinical records to document their health status were used in this study. Enhanced plutonium excretion was associated with more serious chronic diseases, including cardiovascular diseases and other diseases that involved the liver. These chronic diseases were also associated with relatively less plutonium found in the liver relative to the skeleton determined by analyses conducted after autopsy. These data further document health conditions that affect plutonium biokinetics and organ deposition and retention patterns and suggest that health status should be considered when conducting plutonium bioassays as these may alter subsequent dosimetry and risk models. Public Library of Science 2020-11-13 /pmc/articles/PMC7665703/ /pubmed/33186401 http://dx.doi.org/10.1371/journal.pone.0242151 Text en © 2020 Suslova et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Suslova, Klara G.
Efimov, Alexander V.
Sokolova, Alexandra B.
Napier, Bruce A.
Miller, Scott C.
The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association
title The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association
title_full The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association
title_fullStr The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association
title_full_unstemmed The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association
title_short The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association
title_sort effects of chronic diseases on plutonium urinary excretion in former workers of the mayak production association
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665703/
https://www.ncbi.nlm.nih.gov/pubmed/33186401
http://dx.doi.org/10.1371/journal.pone.0242151
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