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The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association
The radiochemical analysis of plutonium activity in urine is the main method for indirect estimation of doses of internal exposure from plutonium incorporation in professional workers. It was previously shown that late-in-life acute diseases, particularly those that affect the liver, can promote acc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665703/ https://www.ncbi.nlm.nih.gov/pubmed/33186401 http://dx.doi.org/10.1371/journal.pone.0242151 |
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author | Suslova, Klara G. Efimov, Alexander V. Sokolova, Alexandra B. Napier, Bruce A. Miller, Scott C. |
author_facet | Suslova, Klara G. Efimov, Alexander V. Sokolova, Alexandra B. Napier, Bruce A. Miller, Scott C. |
author_sort | Suslova, Klara G. |
collection | PubMed |
description | The radiochemical analysis of plutonium activity in urine is the main method for indirect estimation of doses of internal exposure from plutonium incorporation in professional workers. It was previously shown that late-in-life acute diseases, particularly those that affect the liver, can promote accelerated rates of release of plutonium from the liver with enhanced excretion rates. This initial study examines the relationships of some chronic diseases on plutonium excretion as well as the terminal relative distribution of plutonium between the liver and skeleton. Fourteen cases from former workers at the Mayak Production Association (Mayak PA) who provided from 4–9 urine plutonium bioassays for plutonium, had an autopsy conducted after death, and had sufficient clinical records to document their health status were used in this study. Enhanced plutonium excretion was associated with more serious chronic diseases, including cardiovascular diseases and other diseases that involved the liver. These chronic diseases were also associated with relatively less plutonium found in the liver relative to the skeleton determined by analyses conducted after autopsy. These data further document health conditions that affect plutonium biokinetics and organ deposition and retention patterns and suggest that health status should be considered when conducting plutonium bioassays as these may alter subsequent dosimetry and risk models. |
format | Online Article Text |
id | pubmed-7665703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76657032020-11-18 The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association Suslova, Klara G. Efimov, Alexander V. Sokolova, Alexandra B. Napier, Bruce A. Miller, Scott C. PLoS One Research Article The radiochemical analysis of plutonium activity in urine is the main method for indirect estimation of doses of internal exposure from plutonium incorporation in professional workers. It was previously shown that late-in-life acute diseases, particularly those that affect the liver, can promote accelerated rates of release of plutonium from the liver with enhanced excretion rates. This initial study examines the relationships of some chronic diseases on plutonium excretion as well as the terminal relative distribution of plutonium between the liver and skeleton. Fourteen cases from former workers at the Mayak Production Association (Mayak PA) who provided from 4–9 urine plutonium bioassays for plutonium, had an autopsy conducted after death, and had sufficient clinical records to document their health status were used in this study. Enhanced plutonium excretion was associated with more serious chronic diseases, including cardiovascular diseases and other diseases that involved the liver. These chronic diseases were also associated with relatively less plutonium found in the liver relative to the skeleton determined by analyses conducted after autopsy. These data further document health conditions that affect plutonium biokinetics and organ deposition and retention patterns and suggest that health status should be considered when conducting plutonium bioassays as these may alter subsequent dosimetry and risk models. Public Library of Science 2020-11-13 /pmc/articles/PMC7665703/ /pubmed/33186401 http://dx.doi.org/10.1371/journal.pone.0242151 Text en © 2020 Suslova et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Suslova, Klara G. Efimov, Alexander V. Sokolova, Alexandra B. Napier, Bruce A. Miller, Scott C. The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association |
title | The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association |
title_full | The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association |
title_fullStr | The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association |
title_full_unstemmed | The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association |
title_short | The effects of chronic diseases on plutonium urinary excretion in former workers of the Mayak Production Association |
title_sort | effects of chronic diseases on plutonium urinary excretion in former workers of the mayak production association |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665703/ https://www.ncbi.nlm.nih.gov/pubmed/33186401 http://dx.doi.org/10.1371/journal.pone.0242151 |
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