Cargando…
Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria
The Liver Imaging Reporting and Data System (LI-RADS) is widely adopted for the noninvasive diagnosis of hepatocellular carcinoma (HCC). Herein, possible strategies to improve the diagnostic performance of LR-5 without reducing specificity for HCC were investigated. This retrospective study included...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665815/ https://www.ncbi.nlm.nih.gov/pubmed/33186378 http://dx.doi.org/10.1371/journal.pone.0242344 |
_version_ | 1783610034791383040 |
---|---|
author | Park, Jae Hyon Chung, Yong Eun Seo, Nieun Choi, Jin-Young Park, Mi-Suk Kim, Myeong-Jin |
author_facet | Park, Jae Hyon Chung, Yong Eun Seo, Nieun Choi, Jin-Young Park, Mi-Suk Kim, Myeong-Jin |
author_sort | Park, Jae Hyon |
collection | PubMed |
description | The Liver Imaging Reporting and Data System (LI-RADS) is widely adopted for the noninvasive diagnosis of hepatocellular carcinoma (HCC). Herein, possible strategies to improve the diagnostic performance of LR-5 without reducing specificity for HCC were investigated. This retrospective study included 792 patients who underwent gadoxetate disodium-enhanced magnetic resonance imaging. Hepatic observations were categorized according to LI-RADS v2018 and categories were readjusted by upgrading LR4 to LR5 using ancillary features, arterial phase hyperenhancement (APHE) interpreted with subtraction images, indication of no washout when APHE was absent, extension of washout to the transitional phase, and subthreshold growth as a major feature. Based on LI-RADS v2018, LR-5 showed a sensitivity of 71.9% and a specificity of 97.9% for the diagnosis of HCC. Category-readjusted LR-5 after upgrading LR-4 to LR-5 using ancillary features favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted using subtraction images showed significantly increased sensitivity (P<0.001) without decreased specificity (Ps>0.05). The sensitivity of LR-5 can be improved without loss of specificity via category readjustment using AFs favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted with subtraction images. |
format | Online Article Text |
id | pubmed-7665815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76658152020-11-18 Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria Park, Jae Hyon Chung, Yong Eun Seo, Nieun Choi, Jin-Young Park, Mi-Suk Kim, Myeong-Jin PLoS One Research Article The Liver Imaging Reporting and Data System (LI-RADS) is widely adopted for the noninvasive diagnosis of hepatocellular carcinoma (HCC). Herein, possible strategies to improve the diagnostic performance of LR-5 without reducing specificity for HCC were investigated. This retrospective study included 792 patients who underwent gadoxetate disodium-enhanced magnetic resonance imaging. Hepatic observations were categorized according to LI-RADS v2018 and categories were readjusted by upgrading LR4 to LR5 using ancillary features, arterial phase hyperenhancement (APHE) interpreted with subtraction images, indication of no washout when APHE was absent, extension of washout to the transitional phase, and subthreshold growth as a major feature. Based on LI-RADS v2018, LR-5 showed a sensitivity of 71.9% and a specificity of 97.9% for the diagnosis of HCC. Category-readjusted LR-5 after upgrading LR-4 to LR-5 using ancillary features favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted using subtraction images showed significantly increased sensitivity (P<0.001) without decreased specificity (Ps>0.05). The sensitivity of LR-5 can be improved without loss of specificity via category readjustment using AFs favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted with subtraction images. Public Library of Science 2020-11-13 /pmc/articles/PMC7665815/ /pubmed/33186378 http://dx.doi.org/10.1371/journal.pone.0242344 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication. |
spellingShingle | Research Article Park, Jae Hyon Chung, Yong Eun Seo, Nieun Choi, Jin-Young Park, Mi-Suk Kim, Myeong-Jin Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria |
title | Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria |
title_full | Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria |
title_fullStr | Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria |
title_full_unstemmed | Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria |
title_short | Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria |
title_sort | gadoxetic acid-enhanced mri of hepatocellular carcinoma: diagnostic performance of category-adjusted lr-5 using modified criteria |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665815/ https://www.ncbi.nlm.nih.gov/pubmed/33186378 http://dx.doi.org/10.1371/journal.pone.0242344 |
work_keys_str_mv | AT parkjaehyon gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria AT chungyongeun gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria AT seonieun gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria AT choijinyoung gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria AT parkmisuk gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria AT kimmyeongjin gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria |