Cargando…

Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria

The Liver Imaging Reporting and Data System (LI-RADS) is widely adopted for the noninvasive diagnosis of hepatocellular carcinoma (HCC). Herein, possible strategies to improve the diagnostic performance of LR-5 without reducing specificity for HCC were investigated. This retrospective study included...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Jae Hyon, Chung, Yong Eun, Seo, Nieun, Choi, Jin-Young, Park, Mi-Suk, Kim, Myeong-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665815/
https://www.ncbi.nlm.nih.gov/pubmed/33186378
http://dx.doi.org/10.1371/journal.pone.0242344
_version_ 1783610034791383040
author Park, Jae Hyon
Chung, Yong Eun
Seo, Nieun
Choi, Jin-Young
Park, Mi-Suk
Kim, Myeong-Jin
author_facet Park, Jae Hyon
Chung, Yong Eun
Seo, Nieun
Choi, Jin-Young
Park, Mi-Suk
Kim, Myeong-Jin
author_sort Park, Jae Hyon
collection PubMed
description The Liver Imaging Reporting and Data System (LI-RADS) is widely adopted for the noninvasive diagnosis of hepatocellular carcinoma (HCC). Herein, possible strategies to improve the diagnostic performance of LR-5 without reducing specificity for HCC were investigated. This retrospective study included 792 patients who underwent gadoxetate disodium-enhanced magnetic resonance imaging. Hepatic observations were categorized according to LI-RADS v2018 and categories were readjusted by upgrading LR4 to LR5 using ancillary features, arterial phase hyperenhancement (APHE) interpreted with subtraction images, indication of no washout when APHE was absent, extension of washout to the transitional phase, and subthreshold growth as a major feature. Based on LI-RADS v2018, LR-5 showed a sensitivity of 71.9% and a specificity of 97.9% for the diagnosis of HCC. Category-readjusted LR-5 after upgrading LR-4 to LR-5 using ancillary features favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted using subtraction images showed significantly increased sensitivity (P<0.001) without decreased specificity (Ps>0.05). The sensitivity of LR-5 can be improved without loss of specificity via category readjustment using AFs favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted with subtraction images.
format Online
Article
Text
id pubmed-7665815
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-76658152020-11-18 Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria Park, Jae Hyon Chung, Yong Eun Seo, Nieun Choi, Jin-Young Park, Mi-Suk Kim, Myeong-Jin PLoS One Research Article The Liver Imaging Reporting and Data System (LI-RADS) is widely adopted for the noninvasive diagnosis of hepatocellular carcinoma (HCC). Herein, possible strategies to improve the diagnostic performance of LR-5 without reducing specificity for HCC were investigated. This retrospective study included 792 patients who underwent gadoxetate disodium-enhanced magnetic resonance imaging. Hepatic observations were categorized according to LI-RADS v2018 and categories were readjusted by upgrading LR4 to LR5 using ancillary features, arterial phase hyperenhancement (APHE) interpreted with subtraction images, indication of no washout when APHE was absent, extension of washout to the transitional phase, and subthreshold growth as a major feature. Based on LI-RADS v2018, LR-5 showed a sensitivity of 71.9% and a specificity of 97.9% for the diagnosis of HCC. Category-readjusted LR-5 after upgrading LR-4 to LR-5 using ancillary features favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted using subtraction images showed significantly increased sensitivity (P<0.001) without decreased specificity (Ps>0.05). The sensitivity of LR-5 can be improved without loss of specificity via category readjustment using AFs favoring HCC in particular, subthreshold growth as a major feature, extending washout to transitional phase and APHE interpreted with subtraction images. Public Library of Science 2020-11-13 /pmc/articles/PMC7665815/ /pubmed/33186378 http://dx.doi.org/10.1371/journal.pone.0242344 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Park, Jae Hyon
Chung, Yong Eun
Seo, Nieun
Choi, Jin-Young
Park, Mi-Suk
Kim, Myeong-Jin
Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria
title Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria
title_full Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria
title_fullStr Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria
title_full_unstemmed Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria
title_short Gadoxetic acid-enhanced MRI of hepatocellular carcinoma: Diagnostic performance of category-adjusted LR-5 using modified criteria
title_sort gadoxetic acid-enhanced mri of hepatocellular carcinoma: diagnostic performance of category-adjusted lr-5 using modified criteria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665815/
https://www.ncbi.nlm.nih.gov/pubmed/33186378
http://dx.doi.org/10.1371/journal.pone.0242344
work_keys_str_mv AT parkjaehyon gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria
AT chungyongeun gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria
AT seonieun gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria
AT choijinyoung gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria
AT parkmisuk gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria
AT kimmyeongjin gadoxeticacidenhancedmriofhepatocellularcarcinomadiagnosticperformanceofcategoryadjustedlr5usingmodifiedcriteria