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The cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in Ghana

OBJECTIVE: To evaluate the cost-effectiveness of a program intended to reduce intrapartum and neonatal mortality in Accra, Ghana. DESIGN: Quasi-experimental, time-sequence intervention, retrospective cost-effectiveness analysis. METHODS: A program integrating leadership development, clinical skills...

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Autores principales: Bogdewic, Stephanie, Ramaswamy, Rohit, Goodman, David M., Srofenyoh, Emmanuel K., Ucer, Sebnem, Owen, Medge D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665827/
https://www.ncbi.nlm.nih.gov/pubmed/33186395
http://dx.doi.org/10.1371/journal.pone.0242170
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author Bogdewic, Stephanie
Ramaswamy, Rohit
Goodman, David M.
Srofenyoh, Emmanuel K.
Ucer, Sebnem
Owen, Medge D.
author_facet Bogdewic, Stephanie
Ramaswamy, Rohit
Goodman, David M.
Srofenyoh, Emmanuel K.
Ucer, Sebnem
Owen, Medge D.
author_sort Bogdewic, Stephanie
collection PubMed
description OBJECTIVE: To evaluate the cost-effectiveness of a program intended to reduce intrapartum and neonatal mortality in Accra, Ghana. DESIGN: Quasi-experimental, time-sequence intervention, retrospective cost-effectiveness analysis. METHODS: A program integrating leadership development, clinical skills and quality improvement training was piloted at the Greater Accra Regional Hospital from 2013 to 2016. The number of intrapartum and neonatal deaths prevented were estimated using the hospital’s 2012 stillbirth and neonatal mortality rates as a steady-state assumption. The cost-effectiveness of the intervention was calculated as cost per disability-adjusted life year (DALY) averted. In order to test the assumptions included in this analysis, it was subjected to probabilistic and one-way sensitivity analyses. MAIN OUTCOME MEASURES: Incremental cost-effectiveness ratio (ICER), which measures the cost per disability-adjusted life-year averted by the intervention compared to status quo. RESULTS: From 2012 to 2016, there were 45,495 births at the Greater Accra Regional Hospital, of whom 5,734 were admitted to the newborn intensive care unit. The budget for the systems strengthening program was US $1,716,976. Based on program estimates, 307 (±82) neonatal deaths and 84 (±35) stillbirths were prevented, amounting to 12,342 DALYs averted. The systems strengthening intervention was found to be highly cost effective with an ICER of US $139 (±$44), an amount significantly lower than the established threshold of cost-effectiveness of the per capita gross domestic product, which averaged US $1,649 between 2012–2016. The results were found to be sensitive to the following parameters: DALYs averted, number of neonatal deaths, and number of stillbirths. CONCLUSION: An integrated approach to system strengthening in referral hospitals has the potential to reduce neonatal and intrapartum mortality in low resource settings and is likely to be cost-effective. Sustained change can be achieved by building organizational capacity through leadership and clinical training.
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spelling pubmed-76658272020-11-18 The cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in Ghana Bogdewic, Stephanie Ramaswamy, Rohit Goodman, David M. Srofenyoh, Emmanuel K. Ucer, Sebnem Owen, Medge D. PLoS One Research Article OBJECTIVE: To evaluate the cost-effectiveness of a program intended to reduce intrapartum and neonatal mortality in Accra, Ghana. DESIGN: Quasi-experimental, time-sequence intervention, retrospective cost-effectiveness analysis. METHODS: A program integrating leadership development, clinical skills and quality improvement training was piloted at the Greater Accra Regional Hospital from 2013 to 2016. The number of intrapartum and neonatal deaths prevented were estimated using the hospital’s 2012 stillbirth and neonatal mortality rates as a steady-state assumption. The cost-effectiveness of the intervention was calculated as cost per disability-adjusted life year (DALY) averted. In order to test the assumptions included in this analysis, it was subjected to probabilistic and one-way sensitivity analyses. MAIN OUTCOME MEASURES: Incremental cost-effectiveness ratio (ICER), which measures the cost per disability-adjusted life-year averted by the intervention compared to status quo. RESULTS: From 2012 to 2016, there were 45,495 births at the Greater Accra Regional Hospital, of whom 5,734 were admitted to the newborn intensive care unit. The budget for the systems strengthening program was US $1,716,976. Based on program estimates, 307 (±82) neonatal deaths and 84 (±35) stillbirths were prevented, amounting to 12,342 DALYs averted. The systems strengthening intervention was found to be highly cost effective with an ICER of US $139 (±$44), an amount significantly lower than the established threshold of cost-effectiveness of the per capita gross domestic product, which averaged US $1,649 between 2012–2016. The results were found to be sensitive to the following parameters: DALYs averted, number of neonatal deaths, and number of stillbirths. CONCLUSION: An integrated approach to system strengthening in referral hospitals has the potential to reduce neonatal and intrapartum mortality in low resource settings and is likely to be cost-effective. Sustained change can be achieved by building organizational capacity through leadership and clinical training. Public Library of Science 2020-11-13 /pmc/articles/PMC7665827/ /pubmed/33186395 http://dx.doi.org/10.1371/journal.pone.0242170 Text en © 2020 Bogdewic et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Bogdewic, Stephanie
Ramaswamy, Rohit
Goodman, David M.
Srofenyoh, Emmanuel K.
Ucer, Sebnem
Owen, Medge D.
The cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in Ghana
title The cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in Ghana
title_full The cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in Ghana
title_fullStr The cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in Ghana
title_full_unstemmed The cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in Ghana
title_short The cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in Ghana
title_sort cost-effectiveness of a program to reduce intrapartum and neonatal mortality in a referral hospital in ghana
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665827/
https://www.ncbi.nlm.nih.gov/pubmed/33186395
http://dx.doi.org/10.1371/journal.pone.0242170
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