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Acupoint Catgut Embedding for Insomnia: A Meta-Analysis of Randomized Controlled Trials
OBJECTIVES: A Meta-analysis was carried out to evaluate the efficacy and safety of acupoint catgut embedding (ACE), a procedure of embedding sutures made of absorbable materials into the skin tissue of acupoints, on insomnia. METHODS: Relevant clinical randomized controlled trials (RCTs) were compre...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665919/ https://www.ncbi.nlm.nih.gov/pubmed/33204287 http://dx.doi.org/10.1155/2020/5450824 |
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author | Li, Wanrong Li, Zhen Zhang, Huixing Wang, Yue Chen, Hui Xiong, Lize |
author_facet | Li, Wanrong Li, Zhen Zhang, Huixing Wang, Yue Chen, Hui Xiong, Lize |
author_sort | Li, Wanrong |
collection | PubMed |
description | OBJECTIVES: A Meta-analysis was carried out to evaluate the efficacy and safety of acupoint catgut embedding (ACE), a procedure of embedding sutures made of absorbable materials into the skin tissue of acupoints, on insomnia. METHODS: Relevant clinical randomized controlled trials (RCTs) were comprehensively searched from eleven electronic databases (up to 1 March 2020). Two authors independently screened literature, extracted data, and assessed the risk of bias of included studies. Stata 12 and RevMan 5.3.0 software were used for meta-analysis. PyCharm 2019 and Gephi software (version 0.9.2) were used for complex network analysis. RESULTS: Thirty-four RCTs involving 2,655 patients were included. The meta-analysis suggested that ACE induced a better clinical efficacy compared with that in the estazolam tablets (EZ) group (RR = 1.22, 95% CI: 1.13, 1.31) or in the acupuncture (ACU) group (RR = 1.21, 95% CI: 1.14, 1.28) and could significantly reduce the score of Pittsburgh Sleep Quality Index (P < 0.05). ACE resulted in better long-term efficacy compared to that in the EZ group (RR = 1.87, 95% CI: 1.58, 2.22) and ACU group (RR = 1.30, 95% CI: 1.14, 1.48). ACE could significantly reduce the incidence of adverse events (RR = 0.30, 95% CI: 0.15, 0.60) compared with that in the EZ group. Complex network analysis indicated that acupoints of BL23, SP6, PC6, BL15, BL20, BL18, and HT7 were the core acupoints selected in ACE for insomnia. CONCLUSION: The clinical efficacy of ACE for insomnia is better than that of other interventions (EZ and ACU) in both short-term and long-term observations. Considering the efficacy and reduced visits to the clinic by ACE, the present study provides a practical and convenient complementary and alternative therapy for insomnia. This trial is registered with PROSPERO CRD 42020169866. |
format | Online Article Text |
id | pubmed-7665919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-76659192020-11-16 Acupoint Catgut Embedding for Insomnia: A Meta-Analysis of Randomized Controlled Trials Li, Wanrong Li, Zhen Zhang, Huixing Wang, Yue Chen, Hui Xiong, Lize Evid Based Complement Alternat Med Research Article OBJECTIVES: A Meta-analysis was carried out to evaluate the efficacy and safety of acupoint catgut embedding (ACE), a procedure of embedding sutures made of absorbable materials into the skin tissue of acupoints, on insomnia. METHODS: Relevant clinical randomized controlled trials (RCTs) were comprehensively searched from eleven electronic databases (up to 1 March 2020). Two authors independently screened literature, extracted data, and assessed the risk of bias of included studies. Stata 12 and RevMan 5.3.0 software were used for meta-analysis. PyCharm 2019 and Gephi software (version 0.9.2) were used for complex network analysis. RESULTS: Thirty-four RCTs involving 2,655 patients were included. The meta-analysis suggested that ACE induced a better clinical efficacy compared with that in the estazolam tablets (EZ) group (RR = 1.22, 95% CI: 1.13, 1.31) or in the acupuncture (ACU) group (RR = 1.21, 95% CI: 1.14, 1.28) and could significantly reduce the score of Pittsburgh Sleep Quality Index (P < 0.05). ACE resulted in better long-term efficacy compared to that in the EZ group (RR = 1.87, 95% CI: 1.58, 2.22) and ACU group (RR = 1.30, 95% CI: 1.14, 1.48). ACE could significantly reduce the incidence of adverse events (RR = 0.30, 95% CI: 0.15, 0.60) compared with that in the EZ group. Complex network analysis indicated that acupoints of BL23, SP6, PC6, BL15, BL20, BL18, and HT7 were the core acupoints selected in ACE for insomnia. CONCLUSION: The clinical efficacy of ACE for insomnia is better than that of other interventions (EZ and ACU) in both short-term and long-term observations. Considering the efficacy and reduced visits to the clinic by ACE, the present study provides a practical and convenient complementary and alternative therapy for insomnia. This trial is registered with PROSPERO CRD 42020169866. Hindawi 2020-11-06 /pmc/articles/PMC7665919/ /pubmed/33204287 http://dx.doi.org/10.1155/2020/5450824 Text en Copyright © 2020 Wanrong Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Li, Wanrong Li, Zhen Zhang, Huixing Wang, Yue Chen, Hui Xiong, Lize Acupoint Catgut Embedding for Insomnia: A Meta-Analysis of Randomized Controlled Trials |
title | Acupoint Catgut Embedding for Insomnia: A Meta-Analysis of Randomized Controlled Trials |
title_full | Acupoint Catgut Embedding for Insomnia: A Meta-Analysis of Randomized Controlled Trials |
title_fullStr | Acupoint Catgut Embedding for Insomnia: A Meta-Analysis of Randomized Controlled Trials |
title_full_unstemmed | Acupoint Catgut Embedding for Insomnia: A Meta-Analysis of Randomized Controlled Trials |
title_short | Acupoint Catgut Embedding for Insomnia: A Meta-Analysis of Randomized Controlled Trials |
title_sort | acupoint catgut embedding for insomnia: a meta-analysis of randomized controlled trials |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665919/ https://www.ncbi.nlm.nih.gov/pubmed/33204287 http://dx.doi.org/10.1155/2020/5450824 |
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