Cargando…
Parallel ascending spinal pathways for affective touch and pain
The anterolateral pathway consists of ascending spinal tracts that convey pain, temperature and touch information from the spinal cord to the brain(1–4). Projection neurons (PNs) of the anterolateral pathway are attractive therapeutic targets for pain treatment because nociceptive signals emanating...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666110/ https://www.ncbi.nlm.nih.gov/pubmed/33116307 http://dx.doi.org/10.1038/s41586-020-2860-1 |
_version_ | 1783610068637319168 |
---|---|
author | Choi, Seungwon Hachisuka, Junichi Brett, Matthew A. Magee, Alexandra Omori, Yu Iqbal, Noor-ul-Aine Zhang, Dawei DeLisle, Michelle M. Wolfson, Rachel L. Bai, Ling Santiago, Celine Gong, Shiaoching Goulding, Martyn Heintz, Nathaniel Koerber, H. Richard Ross, Sarah E. Ginty, David D. |
author_facet | Choi, Seungwon Hachisuka, Junichi Brett, Matthew A. Magee, Alexandra Omori, Yu Iqbal, Noor-ul-Aine Zhang, Dawei DeLisle, Michelle M. Wolfson, Rachel L. Bai, Ling Santiago, Celine Gong, Shiaoching Goulding, Martyn Heintz, Nathaniel Koerber, H. Richard Ross, Sarah E. Ginty, David D. |
author_sort | Choi, Seungwon |
collection | PubMed |
description | The anterolateral pathway consists of ascending spinal tracts that convey pain, temperature and touch information from the spinal cord to the brain(1–4). Projection neurons (PNs) of the anterolateral pathway are attractive therapeutic targets for pain treatment because nociceptive signals emanating from the periphery channel through these spinal PNs en route to the brain. However, the organizational logic of the anterolateral pathway remains elusive. Here, we show that two PN populations that express structurally related GPCRs, TACR1 and GPR83, form parallel ascending circuit modules that cooperate to convey tactile, thermal and noxious cutaneous signals from the spinal cord to the lateral parabrachial nucleus of the pons (PBN(L)). Axons of Tacr1- and Gpr83-expressing spinoparabrachial (SPB) neurons innervate distinct sets of PBN(L) subnuclei, and strong optogenetic stimulation of their axon terminals induces distinct escape behaviors and autonomic responses. Moreover, Gpr83-expressing SPB neurons are highly sensitive to cutaneous mechanical stimuli and receive strong synaptic inputs from both high- and low-threshold primary mechanosensory neurons. Remarkably, the valence associated with activation of Gpr83-expressing SPB neurons is either positive or negative depending on stimulus intensity. These findings reveal anatomically, physiologically, and functionally distinct SPB tract subdivisions that underlie affective aspects of touch and pain. |
format | Online Article Text |
id | pubmed-7666110 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
record_format | MEDLINE/PubMed |
spelling | pubmed-76661102021-04-28 Parallel ascending spinal pathways for affective touch and pain Choi, Seungwon Hachisuka, Junichi Brett, Matthew A. Magee, Alexandra Omori, Yu Iqbal, Noor-ul-Aine Zhang, Dawei DeLisle, Michelle M. Wolfson, Rachel L. Bai, Ling Santiago, Celine Gong, Shiaoching Goulding, Martyn Heintz, Nathaniel Koerber, H. Richard Ross, Sarah E. Ginty, David D. Nature Article The anterolateral pathway consists of ascending spinal tracts that convey pain, temperature and touch information from the spinal cord to the brain(1–4). Projection neurons (PNs) of the anterolateral pathway are attractive therapeutic targets for pain treatment because nociceptive signals emanating from the periphery channel through these spinal PNs en route to the brain. However, the organizational logic of the anterolateral pathway remains elusive. Here, we show that two PN populations that express structurally related GPCRs, TACR1 and GPR83, form parallel ascending circuit modules that cooperate to convey tactile, thermal and noxious cutaneous signals from the spinal cord to the lateral parabrachial nucleus of the pons (PBN(L)). Axons of Tacr1- and Gpr83-expressing spinoparabrachial (SPB) neurons innervate distinct sets of PBN(L) subnuclei, and strong optogenetic stimulation of their axon terminals induces distinct escape behaviors and autonomic responses. Moreover, Gpr83-expressing SPB neurons are highly sensitive to cutaneous mechanical stimuli and receive strong synaptic inputs from both high- and low-threshold primary mechanosensory neurons. Remarkably, the valence associated with activation of Gpr83-expressing SPB neurons is either positive or negative depending on stimulus intensity. These findings reveal anatomically, physiologically, and functionally distinct SPB tract subdivisions that underlie affective aspects of touch and pain. 2020-10-28 2020-11 /pmc/articles/PMC7666110/ /pubmed/33116307 http://dx.doi.org/10.1038/s41586-020-2860-1 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Choi, Seungwon Hachisuka, Junichi Brett, Matthew A. Magee, Alexandra Omori, Yu Iqbal, Noor-ul-Aine Zhang, Dawei DeLisle, Michelle M. Wolfson, Rachel L. Bai, Ling Santiago, Celine Gong, Shiaoching Goulding, Martyn Heintz, Nathaniel Koerber, H. Richard Ross, Sarah E. Ginty, David D. Parallel ascending spinal pathways for affective touch and pain |
title | Parallel ascending spinal pathways for affective touch and
pain |
title_full | Parallel ascending spinal pathways for affective touch and
pain |
title_fullStr | Parallel ascending spinal pathways for affective touch and
pain |
title_full_unstemmed | Parallel ascending spinal pathways for affective touch and
pain |
title_short | Parallel ascending spinal pathways for affective touch and
pain |
title_sort | parallel ascending spinal pathways for affective touch and
pain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666110/ https://www.ncbi.nlm.nih.gov/pubmed/33116307 http://dx.doi.org/10.1038/s41586-020-2860-1 |
work_keys_str_mv | AT choiseungwon parallelascendingspinalpathwaysforaffectivetouchandpain AT hachisukajunichi parallelascendingspinalpathwaysforaffectivetouchandpain AT brettmatthewa parallelascendingspinalpathwaysforaffectivetouchandpain AT mageealexandra parallelascendingspinalpathwaysforaffectivetouchandpain AT omoriyu parallelascendingspinalpathwaysforaffectivetouchandpain AT iqbalnoorulaine parallelascendingspinalpathwaysforaffectivetouchandpain AT zhangdawei parallelascendingspinalpathwaysforaffectivetouchandpain AT delislemichellem parallelascendingspinalpathwaysforaffectivetouchandpain AT wolfsonrachell parallelascendingspinalpathwaysforaffectivetouchandpain AT bailing parallelascendingspinalpathwaysforaffectivetouchandpain AT santiagoceline parallelascendingspinalpathwaysforaffectivetouchandpain AT gongshiaoching parallelascendingspinalpathwaysforaffectivetouchandpain AT gouldingmartyn parallelascendingspinalpathwaysforaffectivetouchandpain AT heintznathaniel parallelascendingspinalpathwaysforaffectivetouchandpain AT koerberhrichard parallelascendingspinalpathwaysforaffectivetouchandpain AT rosssarahe parallelascendingspinalpathwaysforaffectivetouchandpain AT gintydavidd parallelascendingspinalpathwaysforaffectivetouchandpain |