Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys

Efficacious interventions are urgently needed for the treatment of COVID-19. Here, we report a monoclonal antibody (mAb), MW05, with SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor binding domain (RBD) with angiotensin-converting enzyme 2 (ACE2) receptor. Crosslinking of F...

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Detalles Bibliográficos
Autores principales: Wang, Shuang, Peng, Yun, Wang, Rongjuan, Jiao, Shasha, Wang, Min, Huang, Weijin, Shan, Chao, Jiang, Wen, Li, Zepeng, Gu, Chunying, Chen, Ben, Hu, Xue, Yao, Yanfeng, Min, Juan, Zhang, Huajun, Chen, Ying, Gao, Ge, Tang, Peipei, Li, Gang, Wang, An, Wang, Lan, Zhang, Jinchao, Chen, Shuo, Gui, Xun, Yuan, Zhiming, Liu, Datao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666115/
https://www.ncbi.nlm.nih.gov/pubmed/33188207
http://dx.doi.org/10.1038/s41467-020-19568-1

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