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Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break

Tumor suppressor p53-binding protein 1 (53BP1) is a DNA repair protein essential for the detection, assessment, and resolution of DNA double strand breaks (DSBs). The presence of a DSB is signaled to 53BP1 via a local histone modification cascade that triggers the binding of 53BP1 dimers to chromati...

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Detalles Bibliográficos
Autores principales:	Lou, Jieqiong, Priest, David G., Solano, Ashleigh, Kerjouan, Adèle, Hinde, Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666136/ https://www.ncbi.nlm.nih.gov/pubmed/33188174 http://dx.doi.org/10.1038/s41467-020-19504-3

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