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Superiority of albumin–globulin ratio over albumin to predict mortality in patients undergoing peritoneal dialysis
There is increasing evidence showing that albumin–globulin ratio (AGR) can predict the survival of patients in many types of malignancies. However, no study was done to explore the value of AGR in peritoneal dialysis (PD) patients. A total of 554 incident patients undergoing PD from January 2001 thr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666151/ https://www.ncbi.nlm.nih.gov/pubmed/33188276 http://dx.doi.org/10.1038/s41598-020-73629-5 |
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author | Tsai, Chun-Chieh Hsieh, Yao-Peng Tsai, Shr-Mei Kor, Chew-Teng Chiu, Ping-Fang |
author_facet | Tsai, Chun-Chieh Hsieh, Yao-Peng Tsai, Shr-Mei Kor, Chew-Teng Chiu, Ping-Fang |
author_sort | Tsai, Chun-Chieh |
collection | PubMed |
description | There is increasing evidence showing that albumin–globulin ratio (AGR) can predict the survival of patients in many types of malignancies. However, no study was done to explore the value of AGR in peritoneal dialysis (PD) patients. A total of 554 incident patients undergoing PD from January 2001 through July 2016 were enrolled for this retrospective observational study. The outcomes of interest were all-cause mortality and cardiovascular disease (CVD) mortality. Baseline patient’s socio-demographic data, pharmacotherapy, comorbidities, laboratory and PD-related parameters were collected and used in the multivariate Cox models. The predictive value of AGR on mortality risk was compared with other markers using area under the receiver operating characteristic curve (AUC) analysis. Among the study participants, there were 265 (47.83%) men and the mean follow-up time was 3.87 ± 3.15 years. Univariate Cox analysis showed that low AGR was significantly associated with worse outcomes in terms of all-cause and CVD mortality and it remained an independent predictor in the multivariate models. The fully adjusted hazard ratios for the low AGR group versus high AGR group were 2.12 (95% CI 1.34–3.35, p = 0.001) and 2.58 (95% CI 1.42–4.7, p = 0.002) for all-cause and CVD mortality, respectively. The predictive ability of AGR for mortality risk was superior to that of other biomarkers based on AUC calculations. In conclusion, low AGR was independently associated with higher all-cause and CVD mortality risks in patients undergoing PD. |
format | Online Article Text |
id | pubmed-7666151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-76661512020-11-16 Superiority of albumin–globulin ratio over albumin to predict mortality in patients undergoing peritoneal dialysis Tsai, Chun-Chieh Hsieh, Yao-Peng Tsai, Shr-Mei Kor, Chew-Teng Chiu, Ping-Fang Sci Rep Article There is increasing evidence showing that albumin–globulin ratio (AGR) can predict the survival of patients in many types of malignancies. However, no study was done to explore the value of AGR in peritoneal dialysis (PD) patients. A total of 554 incident patients undergoing PD from January 2001 through July 2016 were enrolled for this retrospective observational study. The outcomes of interest were all-cause mortality and cardiovascular disease (CVD) mortality. Baseline patient’s socio-demographic data, pharmacotherapy, comorbidities, laboratory and PD-related parameters were collected and used in the multivariate Cox models. The predictive value of AGR on mortality risk was compared with other markers using area under the receiver operating characteristic curve (AUC) analysis. Among the study participants, there were 265 (47.83%) men and the mean follow-up time was 3.87 ± 3.15 years. Univariate Cox analysis showed that low AGR was significantly associated with worse outcomes in terms of all-cause and CVD mortality and it remained an independent predictor in the multivariate models. The fully adjusted hazard ratios for the low AGR group versus high AGR group were 2.12 (95% CI 1.34–3.35, p = 0.001) and 2.58 (95% CI 1.42–4.7, p = 0.002) for all-cause and CVD mortality, respectively. The predictive ability of AGR for mortality risk was superior to that of other biomarkers based on AUC calculations. In conclusion, low AGR was independently associated with higher all-cause and CVD mortality risks in patients undergoing PD. Nature Publishing Group UK 2020-11-13 /pmc/articles/PMC7666151/ /pubmed/33188276 http://dx.doi.org/10.1038/s41598-020-73629-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Tsai, Chun-Chieh Hsieh, Yao-Peng Tsai, Shr-Mei Kor, Chew-Teng Chiu, Ping-Fang Superiority of albumin–globulin ratio over albumin to predict mortality in patients undergoing peritoneal dialysis |
title | Superiority of albumin–globulin ratio over albumin to predict mortality in patients undergoing peritoneal dialysis |
title_full | Superiority of albumin–globulin ratio over albumin to predict mortality in patients undergoing peritoneal dialysis |
title_fullStr | Superiority of albumin–globulin ratio over albumin to predict mortality in patients undergoing peritoneal dialysis |
title_full_unstemmed | Superiority of albumin–globulin ratio over albumin to predict mortality in patients undergoing peritoneal dialysis |
title_short | Superiority of albumin–globulin ratio over albumin to predict mortality in patients undergoing peritoneal dialysis |
title_sort | superiority of albumin–globulin ratio over albumin to predict mortality in patients undergoing peritoneal dialysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666151/ https://www.ncbi.nlm.nih.gov/pubmed/33188276 http://dx.doi.org/10.1038/s41598-020-73629-5 |
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