Molecular estimation of neurodegeneration pseudotime in older brains

The temporal molecular changes that lead to disease onset and progression in Alzheimer’s disease (AD) are still unknown. Here we develop a temporal model for these unobserved molecular changes with a manifold learning method applied to RNA-Seq data collected from human postmortem brain samples colle...

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Detalles Bibliográficos
Autores principales: Mukherjee, Sumit, Heath, Laura, Preuss, Christoph, Jayadev, Suman, Garden, Gwenn A., Greenwood, Anna K., Sieberts, Solveig K., De Jager, Philip L., Ertekin-Taner, Nilüfer, Carter, Gregory W., Mangravite, Lara M., Logsdon, Benjamin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666177/
https://www.ncbi.nlm.nih.gov/pubmed/33188183
http://dx.doi.org/10.1038/s41467-020-19622-y

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