IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin

Occurrence of Colorectal cancer (CRC) is relevant with gut microbiota. However, role of IRF3, a key signaling mediator in innate immune sensing, has been barely investigated in CRC. Here, we unexpectedly found that the IRF3 deficient mice are hyper-susceptible to the development of intestinal tumor...

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Detalles Bibliográficos
Autores principales: Tian, Miao, Wang, Xiumei, Sun, Jihong, Lin, Wenlong, Chen, Lumin, Liu, Shengduo, Wu, Ximei, Shi, Liyun, Xu, Pinglong, Cai, Xiujun, Wang, Xiaojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666182/
https://www.ncbi.nlm.nih.gov/pubmed/33188184
http://dx.doi.org/10.1038/s41467-020-19627-7

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