Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study

Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred...

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Detalles Bibliográficos
Autores principales: Cai, Lina, Wheeler, Eleanor, Kerrison, Nicola D., Luan, Jian’an, Deloukas, Panos, Franks, Paul W., Amiano, Pilar, Ardanaz, Eva, Bonet, Catalina, Fagherazzi, Guy, Groop, Leif C., Kaaks, Rudolf, Huerta, José María, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Pala, Valeria, Panico, Salvatore, Rodriguez-Barranco, Miguel, Rolandsson, Olov, Sacerdote, Carlotta, Schulze, Matthias B., Spijkerman, Annemieke M. W., Tjonneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Sharp, Stephen J., Forouhi, Nita G., Riboli, Elio, McCarthy, Mark I., Barroso, Inês, Langenberg, Claudia, Wareham, Nicholas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Data Descriptor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666191/
https://www.ncbi.nlm.nih.gov/pubmed/33188205
http://dx.doi.org/10.1038/s41597-020-00716-7
Descripción
Sumario:Type 2 diabetes (T2D) is a global public health challenge. Whilst the advent of genome-wide association studies has identified >400 genetic variants associated with T2D, our understanding of its biological mechanisms and translational insights is still limited. The EPIC-InterAct project, centred in 8 countries in the European Prospective Investigations into Cancer and Nutrition study, is one of the largest prospective studies of T2D. Established as a nested case-cohort study to investigate the interplay between genetic and lifestyle behavioural factors on the risk of T2D, a total of 12,403 individuals were identified as incident T2D cases, and a representative sub-cohort of 16,154 individuals was selected from a larger cohort of 340,234 participants with a follow-up time of 3.99 million person-years. We describe the results from a genome-wide association analysis between more than 8.9 million SNPs and T2D risk among 22,326 individuals (9,978 cases and 12,348 non-cases) from the EPIC-InterAct study. The summary statistics to be shared provide a valuable resource to facilitate further investigations into the genetics of T2D.

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