Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus

Hypothalamic neurons including proopiomelanocortin (POMC)-producing neurons regulate body weights. The non-motile primary cilium is a critical sensory organelle on the cell surface. An association between ciliary defects and obesity has been suggested, but the underlying mechanisms are not fully und...

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Detalles Bibliográficos
Autores principales: Lee, Chan Hee, Song, Do Kyeong, Park, Chae Beom, Choi, Jeewon, Kang, Gil Myoung, Shin, Sung Hoon, Kwon, Ijoo, Park, Soyoung, Kim, Seongjun, Kim, Ji Ye, Dugu, Hong, Park, Jae Woo, Choi, Jong Han, Min, Se Hee, Sohn, Jong-Woo, Kim, Min-Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666216/
https://www.ncbi.nlm.nih.gov/pubmed/33188191
http://dx.doi.org/10.1038/s41467-020-19638-4

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