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Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations

Parkin (encoded by PRKN) is a ubiquitin ligase that plays an important role in cellular mitochondrial quality control. Mutations in PRKN cause selective dopaminergic cell loss in the substantia nigra and are presumed to induce a decrease in mitochondrial function caused by the defective clearance of...

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Detalles Bibliográficos
Autores principales:	Kano, Masayoshi, Takanashi, Masashi, Oyama, Genko, Yoritaka, Asako, Hatano, Taku, Shiba-Fukushima, Kahori, Nagai, Makiko, Nishiyama, Kazutoshi, Hasegawa, Kazuko, Inoshita, Tsuyoshi, Ishikawa, Kei-ichi, Akamatsu, Wado, Imai, Yuzuru, Bolognin, Silvia, Schwamborn, Jens Christian, Hattori, Nobutaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666226/ https://www.ncbi.nlm.nih.gov/pubmed/33298969 http://dx.doi.org/10.1038/s41531-020-00137-8

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