Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP

Recently, the US Food and Drug Administration (FDA) approved the first small interfering RNA (siRNA) drug, marking a significant milestone in the therapeutic use of RNA interference (RNAi) technology. However, off-target gene silencing by siRNA remains one of the major obstacles in siRNA therapy. Al...

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Detalles Bibliográficos
Autores principales: Zhang, Yao, Teng, Yilan, Xiao, Wangwen, Xu, Beiying, Zhao, Ya, Li, Weihua, Wu, Ligang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666362/
https://www.ncbi.nlm.nih.gov/pubmed/33251041
http://dx.doi.org/10.1016/j.omtn.2020.10.009

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