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Longitudinal assessment of dementia measures in Down syndrome
INTRODUCTION: Early detection of dementia symptoms is critical in Down syndrome (DS) but complicated by clinical assessment barriers. The current study aimed to characterize cognitive and behavioral impairment using longitudinal trajectories comparing several measures of cognitive and behavioral fun...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666427/ https://www.ncbi.nlm.nih.gov/pubmed/33225040 http://dx.doi.org/10.1002/dad2.12075 |
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author | Koehl, Lisa Harp, Jordan Van Pelt, Kathryn L. Head, Elizabeth Schmitt, Frederick A. |
author_facet | Koehl, Lisa Harp, Jordan Van Pelt, Kathryn L. Head, Elizabeth Schmitt, Frederick A. |
author_sort | Koehl, Lisa |
collection | PubMed |
description | INTRODUCTION: Early detection of dementia symptoms is critical in Down syndrome (DS) but complicated by clinical assessment barriers. The current study aimed to characterize cognitive and behavioral impairment using longitudinal trajectories comparing several measures of cognitive and behavioral functioning. METHODS: Measures included global cognitive status (Severe Impairment Battery [SIB]), motor praxis (Brief Praxis Test [BPT]), and clinical dementia informant ratings (Dementia Questionnaire for People with Learning Disabilities [DLD]). One‐year reliability was assessed using a two‐way mixed effect, consistency, single measurement intraclass correlation among non‐demented participants. Longitudinal assessment of SIB, BPT, and DLD was completed using linear mixed effect models. RESULTS: One‐year reliability (n = 52; 21 male) was moderate for DLD (0.69 to 0.75) and good for SIB (0.87) and BPT (0.80). Longitudinal analysis (n = 72) revealed significant age by diagnosis interactions for SIB (F(2, 115.02) = 6.06, P = .003), BPT (F(2, 85.59) = 4.56, P = .013), and DLD (F(2, 103.56) = 4.48, P = .014). SIB progression (PR) had a faster decline in performance versus no‐dementia (ND) (t(159) = −2.87; P = .013). Dementia had a faster decline in BPT performance versus ND (t(112) = −2.46; P = .041). PR showed quickly progressing scores compared to ND (t(128) = −2.86; P = .014). DISCUSSION: Current measures demonstrated moderate to good reliability. Longitudinal analysis revealed that SIB, BPT, and DLD changed with age depending on diagnostic progression; no change rates were dependent on baseline cognition, indicating usefulness across a variety of severity levels in DS. |
format | Online Article Text |
id | pubmed-7666427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76664272020-11-20 Longitudinal assessment of dementia measures in Down syndrome Koehl, Lisa Harp, Jordan Van Pelt, Kathryn L. Head, Elizabeth Schmitt, Frederick A. Alzheimers Dement (Amst) Article INTRODUCTION: Early detection of dementia symptoms is critical in Down syndrome (DS) but complicated by clinical assessment barriers. The current study aimed to characterize cognitive and behavioral impairment using longitudinal trajectories comparing several measures of cognitive and behavioral functioning. METHODS: Measures included global cognitive status (Severe Impairment Battery [SIB]), motor praxis (Brief Praxis Test [BPT]), and clinical dementia informant ratings (Dementia Questionnaire for People with Learning Disabilities [DLD]). One‐year reliability was assessed using a two‐way mixed effect, consistency, single measurement intraclass correlation among non‐demented participants. Longitudinal assessment of SIB, BPT, and DLD was completed using linear mixed effect models. RESULTS: One‐year reliability (n = 52; 21 male) was moderate for DLD (0.69 to 0.75) and good for SIB (0.87) and BPT (0.80). Longitudinal analysis (n = 72) revealed significant age by diagnosis interactions for SIB (F(2, 115.02) = 6.06, P = .003), BPT (F(2, 85.59) = 4.56, P = .013), and DLD (F(2, 103.56) = 4.48, P = .014). SIB progression (PR) had a faster decline in performance versus no‐dementia (ND) (t(159) = −2.87; P = .013). Dementia had a faster decline in BPT performance versus ND (t(112) = −2.46; P = .041). PR showed quickly progressing scores compared to ND (t(128) = −2.86; P = .014). DISCUSSION: Current measures demonstrated moderate to good reliability. Longitudinal analysis revealed that SIB, BPT, and DLD changed with age depending on diagnostic progression; no change rates were dependent on baseline cognition, indicating usefulness across a variety of severity levels in DS. John Wiley and Sons Inc. 2020-11-14 /pmc/articles/PMC7666427/ /pubmed/33225040 http://dx.doi.org/10.1002/dad2.12075 Text en © 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Article Koehl, Lisa Harp, Jordan Van Pelt, Kathryn L. Head, Elizabeth Schmitt, Frederick A. Longitudinal assessment of dementia measures in Down syndrome |
title | Longitudinal assessment of dementia measures in Down syndrome |
title_full | Longitudinal assessment of dementia measures in Down syndrome |
title_fullStr | Longitudinal assessment of dementia measures in Down syndrome |
title_full_unstemmed | Longitudinal assessment of dementia measures in Down syndrome |
title_short | Longitudinal assessment of dementia measures in Down syndrome |
title_sort | longitudinal assessment of dementia measures in down syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666427/ https://www.ncbi.nlm.nih.gov/pubmed/33225040 http://dx.doi.org/10.1002/dad2.12075 |
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