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Association of anemia with mobility capacity in older adults: a Korean nationwide population-based cross-sectional study

BACKGROUND: Over 10% of adults aged ≥65 years have anemia, as defined by the World Health Organization (WHO). As the timed up and go (TUG) test is one of the most widely used tests of mobility, this study investigated whether anemia was associated with mobility capacity assessed using the TUG test i...

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Autores principales: Son, Ki Young, Shin, Dong Wook, Lee, Ji Eun, Kim, Sang Hyuck, Yun, Jae Moon, Cho, Belong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666504/
https://www.ncbi.nlm.nih.gov/pubmed/33187476
http://dx.doi.org/10.1186/s12877-020-01879-z
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author Son, Ki Young
Shin, Dong Wook
Lee, Ji Eun
Kim, Sang Hyuck
Yun, Jae Moon
Cho, Belong
author_facet Son, Ki Young
Shin, Dong Wook
Lee, Ji Eun
Kim, Sang Hyuck
Yun, Jae Moon
Cho, Belong
author_sort Son, Ki Young
collection PubMed
description BACKGROUND: Over 10% of adults aged ≥65 years have anemia, as defined by the World Health Organization (WHO). As the timed up and go (TUG) test is one of the most widely used tests of mobility, this study investigated whether anemia was associated with mobility capacity assessed using the TUG test in older adults. METHODS: Subjects belonging to the Korean National Health Insurance Service-National Health Screening Cohort of the National Health Information Database were reviewed. Subjects were included if they had completed the TUG test as part of the National Screening Program for Transitional Ages in Korea. An abnormal TUG test result was defined as a time of ≥10 s and anemia was defined according to the WHO criteria as a hemoglobin (Hb) concentration of < 13.0 g/dL in men and < 12.0 g/dL in women. The association between anemia and TUG test results was evaluated using four multiple logistic regression models with different levels of adjustment. Stratified analysis according to risk factors was performed. RESULTS: The 81,473 subjects included 41,063 (50.4%) women and 40,410 (49.6%) men. Mean TUG time was 8.44 ± 3.08 s, and abnormal TUG test results were observed in 22,138 (27.2%) subjects. Mean Hb concentration was 13.72 ± 1.41 g/dL, and 10,237 (12.6%) subjects had anemia. U-shaped associations between Hb concentration and TUG test results were observed in both sexes. Subjects with anemia were 19% more likely to have abnormal TUG test results, according to the fully adjusted model (adjusted odds ratio: 1.192, 95% confidence interval: 1.137–1.247). Similar results were observed for both sexes. Stratified analysis showed that subjects with anemia were more likely to have abnormal TUG test results regardless of risk factors. CONCLUSIONS: Individuals with anemia are more likely to have abnormal TUG test results, regardless of risk factors, than individuals without anemia. U-shaped relationships between Hb concentrations and TUG test results were observed in both sexes, although the optimal Hb concentration differed between men and women.
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spelling pubmed-76665042020-11-16 Association of anemia with mobility capacity in older adults: a Korean nationwide population-based cross-sectional study Son, Ki Young Shin, Dong Wook Lee, Ji Eun Kim, Sang Hyuck Yun, Jae Moon Cho, Belong BMC Geriatr Research Article BACKGROUND: Over 10% of adults aged ≥65 years have anemia, as defined by the World Health Organization (WHO). As the timed up and go (TUG) test is one of the most widely used tests of mobility, this study investigated whether anemia was associated with mobility capacity assessed using the TUG test in older adults. METHODS: Subjects belonging to the Korean National Health Insurance Service-National Health Screening Cohort of the National Health Information Database were reviewed. Subjects were included if they had completed the TUG test as part of the National Screening Program for Transitional Ages in Korea. An abnormal TUG test result was defined as a time of ≥10 s and anemia was defined according to the WHO criteria as a hemoglobin (Hb) concentration of < 13.0 g/dL in men and < 12.0 g/dL in women. The association between anemia and TUG test results was evaluated using four multiple logistic regression models with different levels of adjustment. Stratified analysis according to risk factors was performed. RESULTS: The 81,473 subjects included 41,063 (50.4%) women and 40,410 (49.6%) men. Mean TUG time was 8.44 ± 3.08 s, and abnormal TUG test results were observed in 22,138 (27.2%) subjects. Mean Hb concentration was 13.72 ± 1.41 g/dL, and 10,237 (12.6%) subjects had anemia. U-shaped associations between Hb concentration and TUG test results were observed in both sexes. Subjects with anemia were 19% more likely to have abnormal TUG test results, according to the fully adjusted model (adjusted odds ratio: 1.192, 95% confidence interval: 1.137–1.247). Similar results were observed for both sexes. Stratified analysis showed that subjects with anemia were more likely to have abnormal TUG test results regardless of risk factors. CONCLUSIONS: Individuals with anemia are more likely to have abnormal TUG test results, regardless of risk factors, than individuals without anemia. U-shaped relationships between Hb concentrations and TUG test results were observed in both sexes, although the optimal Hb concentration differed between men and women. BioMed Central 2020-11-13 /pmc/articles/PMC7666504/ /pubmed/33187476 http://dx.doi.org/10.1186/s12877-020-01879-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Son, Ki Young
Shin, Dong Wook
Lee, Ji Eun
Kim, Sang Hyuck
Yun, Jae Moon
Cho, Belong
Association of anemia with mobility capacity in older adults: a Korean nationwide population-based cross-sectional study
title Association of anemia with mobility capacity in older adults: a Korean nationwide population-based cross-sectional study
title_full Association of anemia with mobility capacity in older adults: a Korean nationwide population-based cross-sectional study
title_fullStr Association of anemia with mobility capacity in older adults: a Korean nationwide population-based cross-sectional study
title_full_unstemmed Association of anemia with mobility capacity in older adults: a Korean nationwide population-based cross-sectional study
title_short Association of anemia with mobility capacity in older adults: a Korean nationwide population-based cross-sectional study
title_sort association of anemia with mobility capacity in older adults: a korean nationwide population-based cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666504/
https://www.ncbi.nlm.nih.gov/pubmed/33187476
http://dx.doi.org/10.1186/s12877-020-01879-z
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