GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery

Canonical Wnt signaling is emerging as a major regulator of endocytosis. Here, we report that Wnt-induced macropinocytosis is regulated through glycogen synthase kinase 3 (GSK3) and the β-catenin destruction complex. We find that mutation of Axin1, a tumor suppressor and component of the destruction...

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Detalles Bibliográficos
Autores principales: Albrecht, Lauren V., Tejeda-Muñoz, Nydia, Bui, Maggie H., Cicchetto, Andrew C., Di Biagio, Daniele, Colozza, Gabriele, Schmid, Ernst, Piccolo, Stefano, Christofk, Heather R., De Robertis, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666578/
https://www.ncbi.nlm.nih.gov/pubmed/32726636
http://dx.doi.org/10.1016/j.celrep.2020.107973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666578/
https://www.ncbi.nlm.nih.gov/pubmed/32726636
http://dx.doi.org/10.1016/j.celrep.2020.107973

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