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Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs

Lung transplantation remains the best treatment option for end-stage lung disease; however, is limited by a shortage of donor grafts. Ex situ lung perfusion, also known as ex vivo lung perfusion, has been shown to allow for the safe evaluation and reconditioning of extended criteria donor lungs, inc...

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Autores principales: Buchko, Max T., Boroumand, Nasim, Cheng, Jeffrey C., Hirji, Alim, Halloran, Kieran, Freed, Darren H., Nagendran, Jayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666579/
https://www.ncbi.nlm.nih.gov/pubmed/33188221
http://dx.doi.org/10.1038/s41467-020-19581-4
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author Buchko, Max T.
Boroumand, Nasim
Cheng, Jeffrey C.
Hirji, Alim
Halloran, Kieran
Freed, Darren H.
Nagendran, Jayan
author_facet Buchko, Max T.
Boroumand, Nasim
Cheng, Jeffrey C.
Hirji, Alim
Halloran, Kieran
Freed, Darren H.
Nagendran, Jayan
author_sort Buchko, Max T.
collection PubMed
description Lung transplantation remains the best treatment option for end-stage lung disease; however, is limited by a shortage of donor grafts. Ex situ lung perfusion, also known as ex vivo lung perfusion, has been shown to allow for the safe evaluation and reconditioning of extended criteria donor lungs, increasing donor utilization. Negative pressure ventilation ex situ lung perfusion has been shown, preclinically, to result in less ventilator-induced lung injury than positive pressure ventilation. Here we demonstrate that, in a single-arm interventional study (ClinicalTrials.gov number NCT03293043) of 12 extended criteria donor human lungs, negative pressure ventilation ex situ lung perfusion allows for preservation and evaluation of donor lungs with all grafts and patients surviving to 30 days and recovered to discharge from hospital. This trial also demonstrates that ex situ lung perfusion is safe and feasible with no patients demonstrating primary graft dysfunction scores grade 3 at 72 h or requiring post-operative extracorporeal membrane oxygenation.
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spelling pubmed-76665792020-11-24 Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs Buchko, Max T. Boroumand, Nasim Cheng, Jeffrey C. Hirji, Alim Halloran, Kieran Freed, Darren H. Nagendran, Jayan Nat Commun Article Lung transplantation remains the best treatment option for end-stage lung disease; however, is limited by a shortage of donor grafts. Ex situ lung perfusion, also known as ex vivo lung perfusion, has been shown to allow for the safe evaluation and reconditioning of extended criteria donor lungs, increasing donor utilization. Negative pressure ventilation ex situ lung perfusion has been shown, preclinically, to result in less ventilator-induced lung injury than positive pressure ventilation. Here we demonstrate that, in a single-arm interventional study (ClinicalTrials.gov number NCT03293043) of 12 extended criteria donor human lungs, negative pressure ventilation ex situ lung perfusion allows for preservation and evaluation of donor lungs with all grafts and patients surviving to 30 days and recovered to discharge from hospital. This trial also demonstrates that ex situ lung perfusion is safe and feasible with no patients demonstrating primary graft dysfunction scores grade 3 at 72 h or requiring post-operative extracorporeal membrane oxygenation. Nature Publishing Group UK 2020-11-13 /pmc/articles/PMC7666579/ /pubmed/33188221 http://dx.doi.org/10.1038/s41467-020-19581-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Buchko, Max T.
Boroumand, Nasim
Cheng, Jeffrey C.
Hirji, Alim
Halloran, Kieran
Freed, Darren H.
Nagendran, Jayan
Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs
title Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs
title_full Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs
title_fullStr Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs
title_full_unstemmed Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs
title_short Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs
title_sort clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666579/
https://www.ncbi.nlm.nih.gov/pubmed/33188221
http://dx.doi.org/10.1038/s41467-020-19581-4
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