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Association between Gastrointestinal Phenotypes and Weight Gain in Younger Adults: A Prospective 4-year Cohort Study

BACKGROUND/OBJECTIVES: Gastrointestinal phenotypes have previously been associated with obesity, however it is unknown if these phenotypes are a cause or a consequence of obesity and weight gain. Our aim was to assess whether these gastrointestinal phenotypes are associated with future weight gain i...

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Autores principales: Pajot, Gregory, Camilleri, Michael, Calderon, Gerardo, Davis, Judith, Eckert, Deborah, Burton, Duane, Acosta, Andres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666652/
https://www.ncbi.nlm.nih.gov/pubmed/32415254
http://dx.doi.org/10.1038/s41366-020-0593-8
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author Pajot, Gregory
Camilleri, Michael
Calderon, Gerardo
Davis, Judith
Eckert, Deborah
Burton, Duane
Acosta, Andres
author_facet Pajot, Gregory
Camilleri, Michael
Calderon, Gerardo
Davis, Judith
Eckert, Deborah
Burton, Duane
Acosta, Andres
author_sort Pajot, Gregory
collection PubMed
description BACKGROUND/OBJECTIVES: Gastrointestinal phenotypes have previously been associated with obesity, however it is unknown if these phenotypes are a cause or a consequence of obesity and weight gain. Our aim was to assess whether these gastrointestinal phenotypes are associated with future weight gain in younger adults. SUBJECTS/METHODS: At baseline, 126 adult participants under the age of 35 were weighed and underwent measurement of gastrointestinal phenotypes including gastric emptying (GE), gastric volume, satiation, satiety and gastrointestinal hormones. Patients were re-appraised after median 4.4 years unless, during the period of follow up, they participated in a formal weight loss program, received obesity-weight loss interventions, or developed a health condition likely to affect weight. Participants were dichotomized into two groups for each phenotype at the median of each phenotype. RESULTS: In total, 60 participants met criteria for inclusion and were evaluated after a median of 4.4 years [IQR: 3.5 to 5],36 participants were excluded due to conditions that would abnormally affect weight during study period including pregnancy and weight loss treatment, and 30 participants were lost to prospective follow-up. Faster GE was significantly associated with weight gain. Those with faster GE at baseline (n=30) gained a median of 9.6 kg [3.1 to 14.9] compared to those with slower GE at baseline (n=30) who gained a median of 2.8 kg [−4.6 to 9.2] (p=0.03), over the follow-up period. There was no association between the other phenotypes and weight gain. CONCLUSIONS: In adults ≤35 years old, faster gastric emptying is associated with significantly increased weight gain over the medium term. This provides supportive evidence for the role of gastric emptying in weight gain and development of obesity.
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spelling pubmed-76666522020-11-25 Association between Gastrointestinal Phenotypes and Weight Gain in Younger Adults: A Prospective 4-year Cohort Study Pajot, Gregory Camilleri, Michael Calderon, Gerardo Davis, Judith Eckert, Deborah Burton, Duane Acosta, Andres Int J Obes (Lond) Article BACKGROUND/OBJECTIVES: Gastrointestinal phenotypes have previously been associated with obesity, however it is unknown if these phenotypes are a cause or a consequence of obesity and weight gain. Our aim was to assess whether these gastrointestinal phenotypes are associated with future weight gain in younger adults. SUBJECTS/METHODS: At baseline, 126 adult participants under the age of 35 were weighed and underwent measurement of gastrointestinal phenotypes including gastric emptying (GE), gastric volume, satiation, satiety and gastrointestinal hormones. Patients were re-appraised after median 4.4 years unless, during the period of follow up, they participated in a formal weight loss program, received obesity-weight loss interventions, or developed a health condition likely to affect weight. Participants were dichotomized into two groups for each phenotype at the median of each phenotype. RESULTS: In total, 60 participants met criteria for inclusion and were evaluated after a median of 4.4 years [IQR: 3.5 to 5],36 participants were excluded due to conditions that would abnormally affect weight during study period including pregnancy and weight loss treatment, and 30 participants were lost to prospective follow-up. Faster GE was significantly associated with weight gain. Those with faster GE at baseline (n=30) gained a median of 9.6 kg [3.1 to 14.9] compared to those with slower GE at baseline (n=30) who gained a median of 2.8 kg [−4.6 to 9.2] (p=0.03), over the follow-up period. There was no association between the other phenotypes and weight gain. CONCLUSIONS: In adults ≤35 years old, faster gastric emptying is associated with significantly increased weight gain over the medium term. This provides supportive evidence for the role of gastric emptying in weight gain and development of obesity. 2020-05-15 2020-12 /pmc/articles/PMC7666652/ /pubmed/32415254 http://dx.doi.org/10.1038/s41366-020-0593-8 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Pajot, Gregory
Camilleri, Michael
Calderon, Gerardo
Davis, Judith
Eckert, Deborah
Burton, Duane
Acosta, Andres
Association between Gastrointestinal Phenotypes and Weight Gain in Younger Adults: A Prospective 4-year Cohort Study
title Association between Gastrointestinal Phenotypes and Weight Gain in Younger Adults: A Prospective 4-year Cohort Study
title_full Association between Gastrointestinal Phenotypes and Weight Gain in Younger Adults: A Prospective 4-year Cohort Study
title_fullStr Association between Gastrointestinal Phenotypes and Weight Gain in Younger Adults: A Prospective 4-year Cohort Study
title_full_unstemmed Association between Gastrointestinal Phenotypes and Weight Gain in Younger Adults: A Prospective 4-year Cohort Study
title_short Association between Gastrointestinal Phenotypes and Weight Gain in Younger Adults: A Prospective 4-year Cohort Study
title_sort association between gastrointestinal phenotypes and weight gain in younger adults: a prospective 4-year cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666652/
https://www.ncbi.nlm.nih.gov/pubmed/32415254
http://dx.doi.org/10.1038/s41366-020-0593-8
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