Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

Patients with type-2 diabetes mellitus (T2DM) display chronic low-grade inflammation induced by activation of the innate immune system. Toll-like receptor (TLR)4 is a pattern recognition receptor that plays a vital part in activation of the innate immune system. Results from animal and computer-simu...

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Autores principales: Wang, Zhaoping, Ni, Xiaolin, Zhang, Li, Sun, Liang, Zhu, Xiaoquan, Zhou, Qi, Yang, Ze, Yuan, Huiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666984/
https://www.ncbi.nlm.nih.gov/pubmed/33204132
http://dx.doi.org/10.2147/DMSO.S279104
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author Wang, Zhaoping
Ni, Xiaolin
Zhang, Li
Sun, Liang
Zhu, Xiaoquan
Zhou, Qi
Yang, Ze
Yuan, Huiping
author_facet Wang, Zhaoping
Ni, Xiaolin
Zhang, Li
Sun, Liang
Zhu, Xiaoquan
Zhou, Qi
Yang, Ze
Yuan, Huiping
author_sort Wang, Zhaoping
collection PubMed
description Patients with type-2 diabetes mellitus (T2DM) display chronic low-grade inflammation induced by activation of the innate immune system. Toll-like receptor (TLR)4 is a pattern recognition receptor that plays a vital part in activation of the innate immune system. Results from animal and computer-simulation studies have demonstrated that targeting TLR4 to block the TLR4-nuclear factor-kappa B (NF-κB) pathway reduces the inflammatory response and complications associated with T2DM. Therefore, TLR4-targeted therapy has broad prospects. Here, we reviewed the role of TLR4 in inflammation during chronic hyperglycemia in T2DM and its therapeutic prospects.
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spelling pubmed-76669842020-11-16 Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective Wang, Zhaoping Ni, Xiaolin Zhang, Li Sun, Liang Zhu, Xiaoquan Zhou, Qi Yang, Ze Yuan, Huiping Diabetes Metab Syndr Obes Review Patients with type-2 diabetes mellitus (T2DM) display chronic low-grade inflammation induced by activation of the innate immune system. Toll-like receptor (TLR)4 is a pattern recognition receptor that plays a vital part in activation of the innate immune system. Results from animal and computer-simulation studies have demonstrated that targeting TLR4 to block the TLR4-nuclear factor-kappa B (NF-κB) pathway reduces the inflammatory response and complications associated with T2DM. Therefore, TLR4-targeted therapy has broad prospects. Here, we reviewed the role of TLR4 in inflammation during chronic hyperglycemia in T2DM and its therapeutic prospects. Dove 2020-11-10 /pmc/articles/PMC7666984/ /pubmed/33204132 http://dx.doi.org/10.2147/DMSO.S279104 Text en © 2020 Wang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Wang, Zhaoping
Ni, Xiaolin
Zhang, Li
Sun, Liang
Zhu, Xiaoquan
Zhou, Qi
Yang, Ze
Yuan, Huiping
Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_full Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_fullStr Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_full_unstemmed Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_short Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective
title_sort toll-like receptor 4 and inflammatory micro-environment of pancreatic islets in type-2 diabetes mellitus: a therapeutic perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7666984/
https://www.ncbi.nlm.nih.gov/pubmed/33204132
http://dx.doi.org/10.2147/DMSO.S279104
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