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Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes
Vibrio cholerae serogroup O1 is responsible for epidemic and pandemic cholera and remains a global public health threat. This organism has been well established as a resident flora of the aquatic environment that alters its phenotypic and genotypic attributes for better adaptation to the environment...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667034/ https://www.ncbi.nlm.nih.gov/pubmed/33172996 http://dx.doi.org/10.1128/mBio.01227-20 |
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author | Morita, Daichi Morita, Masatomo Alam, Munirul Mukhopadhyay, Asish K. Johura, Fatema-tuz Sultana, Marzia Monira, Shirajum Ahmed, Niyaz Chowdhury, Goutam Dutta, Shanta Ramamurthy, Thandavarayan Samanta, Prosenjit Takahashi, Eizo Okamoto, Keinosuke Izumiya, Hidemasa Ohnishi, Makoto |
author_facet | Morita, Daichi Morita, Masatomo Alam, Munirul Mukhopadhyay, Asish K. Johura, Fatema-tuz Sultana, Marzia Monira, Shirajum Ahmed, Niyaz Chowdhury, Goutam Dutta, Shanta Ramamurthy, Thandavarayan Samanta, Prosenjit Takahashi, Eizo Okamoto, Keinosuke Izumiya, Hidemasa Ohnishi, Makoto |
author_sort | Morita, Daichi |
collection | PubMed |
description | Vibrio cholerae serogroup O1 is responsible for epidemic and pandemic cholera and remains a global public health threat. This organism has been well established as a resident flora of the aquatic environment that alters its phenotypic and genotypic attributes for better adaptation to the environment. To reveal the diversity of clinical isolates of V. cholerae O1 in the Bay of Bengal, we performed whole-genome sequencing of isolates from Kolkata, India, and Dhaka, Bangladesh, collected between 2009 and 2016. Comparison with global isolates by phylogenetic analysis placed the current isolates in two Asian lineages, with lineages 1 and 2 predominant in Dhaka and Kolkata, respectively. Each lineage possessed different genetic traits in the cholera toxin B subunit gene, Vibrio seventh pandemic island II, integrative and conjugative element, and antibiotic-resistant genes. Thus, although recent global transmission of V. cholerae O1 from South Asia has been attributed only to isolates of lineage 2, another distinct lineage exists in Bengal. |
format | Online Article Text |
id | pubmed-7667034 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-76670342020-11-17 Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes Morita, Daichi Morita, Masatomo Alam, Munirul Mukhopadhyay, Asish K. Johura, Fatema-tuz Sultana, Marzia Monira, Shirajum Ahmed, Niyaz Chowdhury, Goutam Dutta, Shanta Ramamurthy, Thandavarayan Samanta, Prosenjit Takahashi, Eizo Okamoto, Keinosuke Izumiya, Hidemasa Ohnishi, Makoto mBio Research Article Vibrio cholerae serogroup O1 is responsible for epidemic and pandemic cholera and remains a global public health threat. This organism has been well established as a resident flora of the aquatic environment that alters its phenotypic and genotypic attributes for better adaptation to the environment. To reveal the diversity of clinical isolates of V. cholerae O1 in the Bay of Bengal, we performed whole-genome sequencing of isolates from Kolkata, India, and Dhaka, Bangladesh, collected between 2009 and 2016. Comparison with global isolates by phylogenetic analysis placed the current isolates in two Asian lineages, with lineages 1 and 2 predominant in Dhaka and Kolkata, respectively. Each lineage possessed different genetic traits in the cholera toxin B subunit gene, Vibrio seventh pandemic island II, integrative and conjugative element, and antibiotic-resistant genes. Thus, although recent global transmission of V. cholerae O1 from South Asia has been attributed only to isolates of lineage 2, another distinct lineage exists in Bengal. American Society for Microbiology 2020-11-10 /pmc/articles/PMC7667034/ /pubmed/33172996 http://dx.doi.org/10.1128/mBio.01227-20 Text en Copyright © 2020 Morita et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Article Morita, Daichi Morita, Masatomo Alam, Munirul Mukhopadhyay, Asish K. Johura, Fatema-tuz Sultana, Marzia Monira, Shirajum Ahmed, Niyaz Chowdhury, Goutam Dutta, Shanta Ramamurthy, Thandavarayan Samanta, Prosenjit Takahashi, Eizo Okamoto, Keinosuke Izumiya, Hidemasa Ohnishi, Makoto Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes |
title | Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes |
title_full | Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes |
title_fullStr | Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes |
title_full_unstemmed | Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes |
title_short | Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes |
title_sort | whole-genome analysis of clinical vibrio cholerae o1 in kolkata, india, and dhaka, bangladesh, reveals two lineages of circulating strains, indicating variation in genomic attributes |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667034/ https://www.ncbi.nlm.nih.gov/pubmed/33172996 http://dx.doi.org/10.1128/mBio.01227-20 |
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