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Safety, Efficacy, and Preventive Role of Subcutaneous and Sublingual Allergen Immunotherapy for the Treatment of Pediatric Asthma

Allergen-specific immunotherapy is currently the only treatment with the potential to modify and prevent progression of allergic asthma in children. In clinical practice, it is available in two forms: subcutaneous immunotherapy and sublingual immunotherapy. Trials and meta-analyses showed both the s...

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Autores principales: Giannetti, Arianna, Ricci, Giampaolo, Procaccianti, Michela, Santoro, Angelica, Caffarelli, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667503/
https://www.ncbi.nlm.nih.gov/pubmed/33204114
http://dx.doi.org/10.2147/JAA.S234280
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author Giannetti, Arianna
Ricci, Giampaolo
Procaccianti, Michela
Santoro, Angelica
Caffarelli, Carlo
author_facet Giannetti, Arianna
Ricci, Giampaolo
Procaccianti, Michela
Santoro, Angelica
Caffarelli, Carlo
author_sort Giannetti, Arianna
collection PubMed
description Allergen-specific immunotherapy is currently the only treatment with the potential to modify and prevent progression of allergic asthma in children. In clinical practice, it is available in two forms: subcutaneous immunotherapy and sublingual immunotherapy. Trials and meta-analyses showed both the safety and the short- and long-term benefits of allergen-specific immunotherapy in asthmatic children. However, its use and role in asthma remains controversial, since studies are largely heterogeneous. This is mainly due to the lack of consensus on the optimal primary outcome to be considered for clinical trials evaluating the efficacy of allergen-specific immunotherapy in asthma. Therefore, well-conducted researchis needed using standardized and validated tools to evaluate key outcomes in asthmatic children.
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spelling pubmed-76675032020-11-16 Safety, Efficacy, and Preventive Role of Subcutaneous and Sublingual Allergen Immunotherapy for the Treatment of Pediatric Asthma Giannetti, Arianna Ricci, Giampaolo Procaccianti, Michela Santoro, Angelica Caffarelli, Carlo J Asthma Allergy Review Allergen-specific immunotherapy is currently the only treatment with the potential to modify and prevent progression of allergic asthma in children. In clinical practice, it is available in two forms: subcutaneous immunotherapy and sublingual immunotherapy. Trials and meta-analyses showed both the safety and the short- and long-term benefits of allergen-specific immunotherapy in asthmatic children. However, its use and role in asthma remains controversial, since studies are largely heterogeneous. This is mainly due to the lack of consensus on the optimal primary outcome to be considered for clinical trials evaluating the efficacy of allergen-specific immunotherapy in asthma. Therefore, well-conducted researchis needed using standardized and validated tools to evaluate key outcomes in asthmatic children. Dove 2020-11-10 /pmc/articles/PMC7667503/ /pubmed/33204114 http://dx.doi.org/10.2147/JAA.S234280 Text en © 2020 Giannetti et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Giannetti, Arianna
Ricci, Giampaolo
Procaccianti, Michela
Santoro, Angelica
Caffarelli, Carlo
Safety, Efficacy, and Preventive Role of Subcutaneous and Sublingual Allergen Immunotherapy for the Treatment of Pediatric Asthma
title Safety, Efficacy, and Preventive Role of Subcutaneous and Sublingual Allergen Immunotherapy for the Treatment of Pediatric Asthma
title_full Safety, Efficacy, and Preventive Role of Subcutaneous and Sublingual Allergen Immunotherapy for the Treatment of Pediatric Asthma
title_fullStr Safety, Efficacy, and Preventive Role of Subcutaneous and Sublingual Allergen Immunotherapy for the Treatment of Pediatric Asthma
title_full_unstemmed Safety, Efficacy, and Preventive Role of Subcutaneous and Sublingual Allergen Immunotherapy for the Treatment of Pediatric Asthma
title_short Safety, Efficacy, and Preventive Role of Subcutaneous and Sublingual Allergen Immunotherapy for the Treatment of Pediatric Asthma
title_sort safety, efficacy, and preventive role of subcutaneous and sublingual allergen immunotherapy for the treatment of pediatric asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667503/
https://www.ncbi.nlm.nih.gov/pubmed/33204114
http://dx.doi.org/10.2147/JAA.S234280
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