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Multivesicular Liposome (Depofoam) in Human Diseases

Drug development is a key point in the research of new therapeutic treatments for increasing maximum drug loading and prolonged drug effect. Encapsulation of drugs into multivesicular liposomes (DepoFoam) is a nanotechnology that allow delivery of the active constituent at a sufficient concentration...

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Detalles Bibliográficos
Autores principales: Salehi, Bahare, Mishra, Abhay P., Nigam, Manisha, Kobarfard, Farzad, Javed, Zeeshan, Rajabi, Sadegh, Khan, Khushbukhat, Ashfaq, Hafiz Ahsan, Ahmad, Toqeer, Pezzani , Raffaele, Ramírez-Alarcón, Karina, Martorell, Miquel, Cho, William C., Ayatollahi, Seyed Abdulmajid, Sharifi-Rad, Javad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667536/
https://www.ncbi.nlm.nih.gov/pubmed/33224207
http://dx.doi.org/10.22037/ijpr.2020.112291.13663
Descripción
Sumario:Drug development is a key point in the research of new therapeutic treatments for increasing maximum drug loading and prolonged drug effect. Encapsulation of drugs into multivesicular liposomes (DepoFoam) is a nanotechnology that allow delivery of the active constituent at a sufficient concentration during the entire treatment period. This guarantees the reduction of drug administration frequency, a very important factor in a prolonged treatment. Currently, diverse DepoFoam drugs are approved for clinical use against neurological diseases and for post-surgical pain management while other are under development for reducing surgical bleeding and for post-surgical analgesia. Also, on pre-clinical trials on cancer DepoFoam can improve bioavailability and stability of the drug molecules minimizing side effects by site-specific targeted delivery. In the current work, available literature on structure, preparation and pharmacokinetics of DepoFoam are reviewed. Moreover, we investigated approved DepoFoam formulations and preclinical studies with this nanotechnology.