Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020

We analysed factors associated with neutralising antibody levels in 330 convalescent plasma donors. Women and younger donors were more likely not to have measurable neutralising antibodies, while higher antibody levels were observed in men, in older donors and in those who had been hospitalised. The...

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Autores principales: Mehew, Jennifer, Johnson, Rachel, Roberts, David, Harvala, Heli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667632/
https://www.ncbi.nlm.nih.gov/pubmed/33183404
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.45.2001754
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author Mehew, Jennifer
Johnson, Rachel
Roberts, David
Harvala, Heli
author_facet Mehew, Jennifer
Johnson, Rachel
Roberts, David
Harvala, Heli
author_sort Mehew, Jennifer
collection PubMed
description We analysed factors associated with neutralising antibody levels in 330 convalescent plasma donors. Women and younger donors were more likely not to have measurable neutralising antibodies, while higher antibody levels were observed in men, in older donors and in those who had been hospitalised. These data will be of value in the timely recruitment of convalescent plasma donors most likely to have high levels of neutralising antibodies for ongoing studies investigating its effectiveness.
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spelling pubmed-76676322020-11-18 Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020 Mehew, Jennifer Johnson, Rachel Roberts, David Harvala, Heli Euro Surveill Rapid Communication We analysed factors associated with neutralising antibody levels in 330 convalescent plasma donors. Women and younger donors were more likely not to have measurable neutralising antibodies, while higher antibody levels were observed in men, in older donors and in those who had been hospitalised. These data will be of value in the timely recruitment of convalescent plasma donors most likely to have high levels of neutralising antibodies for ongoing studies investigating its effectiveness. European Centre for Disease Prevention and Control (ECDC) 2020-11-12 /pmc/articles/PMC7667632/ /pubmed/33183404 http://dx.doi.org/10.2807/1560-7917.ES.2020.25.45.2001754 Text en This article is copyright of the authors or their affiliated institutions, 2020. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Mehew, Jennifer
Johnson, Rachel
Roberts, David
Harvala, Heli
Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020
title Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020
title_full Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020
title_fullStr Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020
title_full_unstemmed Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020
title_short Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020
title_sort convalescent plasma for covid-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, england, 22 april to 12 may 2020
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667632/
https://www.ncbi.nlm.nih.gov/pubmed/33183404
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.45.2001754
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