Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35

[Image: see text] FK506-binding protein 35, FKBP35, has been implicated as an essential malarial enzyme. Rapamycin and FK506 exhibit antiplasmodium activity in cultured parasites. However, due to the highly conserved nature of the binding pockets of FKBPs and the immunosuppressive properties of thes...

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Detalles Bibliográficos
Autores principales: Atack, Thomas C., Raymond, Donald D., Blomquist, Christa A., Pasaje, Charisse Flerida, McCarren, Patrick R., Moroco, Jamie, Befekadu, Henock B., Robinson, Foxy P., Pal, Debjani, Esherick, Lisl Y., Ianari, Alessandra, Niles, Jacquin C., Sellers, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667655/
https://www.ncbi.nlm.nih.gov/pubmed/33209191
http://dx.doi.org/10.1021/acsmedchemlett.0c00272

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