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Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study

BACKGROUND: FGF23 controls serum l,25(OH)(2)D(3) levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)(2)D(3) in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction...

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Autores principales: Saki, Forough, Salehifar, Azita, Kassaee, Seyed Reza, Omrani, Gholamhossein Ranjbar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667728/
https://www.ncbi.nlm.nih.gov/pubmed/33198660
http://dx.doi.org/10.1186/s12882-020-02101-3
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author Saki, Forough
Salehifar, Azita
Kassaee, Seyed Reza
Omrani, Gholamhossein Ranjbar
author_facet Saki, Forough
Salehifar, Azita
Kassaee, Seyed Reza
Omrani, Gholamhossein Ranjbar
author_sort Saki, Forough
collection PubMed
description BACKGROUND: FGF23 controls serum l,25(OH)(2)D(3) levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)(2)D(3) in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the absence of proper PTH functioning in human. METHODS: In this case-control study, 25 major-beta thalassemia patients with hypoparathyroidism were age- and gender-matched with major-beta thalassemia patients having normal parathyroid function. Biochemical studies assessed the serum calcium, albumin, phosphorus, alkaline phosphatase, PTH, FGF23, 25(OH) D, 1,25(OH)2D3, ferritin, and the fractional excretion of phosphorous. RESULTS: FGF23 was higher in the patients with hypoparathyroidism than the controls (P = 0.002). The fractional excretion of phosphorous was lower in patients with hypoparathyroidism, despite the high level of FGF23 (P = 0.001). There was a correlation between serum 1,25(OH)2D3 and FGF23 with ferritin in the controls (P = < 0.001and P = < 0.001, respectively). CONCLUSIONS: The present study showed a strong positive correlation between serum ferritin and levels of FGF23 and 1,25(OH)2D3. We hypothesized that ferritin could have a stimulatory effect on the production of 1,25(OH)2D3. Moreover, a rise in FGF23 in patients with thalassemia, might be either associated with the stimulating effect of PTH and 1,25(OH)2D3, or directly related to the stimulating effect of ferritin.
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spelling pubmed-76677282020-11-17 Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study Saki, Forough Salehifar, Azita Kassaee, Seyed Reza Omrani, Gholamhossein Ranjbar BMC Nephrol Research Article BACKGROUND: FGF23 controls serum l,25(OH)(2)D(3) levels and phosphate homeostasis. This study evaluates the effects of ferritin on intact PTH, FGF23, and l,25(OH)(2)D(3) in patients with major thalassemia. It also evaluates FGF23 changes in patients with hypoparathyroidism to clarify the interaction between FGF23 and PTH in the absence of proper PTH functioning in human. METHODS: In this case-control study, 25 major-beta thalassemia patients with hypoparathyroidism were age- and gender-matched with major-beta thalassemia patients having normal parathyroid function. Biochemical studies assessed the serum calcium, albumin, phosphorus, alkaline phosphatase, PTH, FGF23, 25(OH) D, 1,25(OH)2D3, ferritin, and the fractional excretion of phosphorous. RESULTS: FGF23 was higher in the patients with hypoparathyroidism than the controls (P = 0.002). The fractional excretion of phosphorous was lower in patients with hypoparathyroidism, despite the high level of FGF23 (P = 0.001). There was a correlation between serum 1,25(OH)2D3 and FGF23 with ferritin in the controls (P = < 0.001and P = < 0.001, respectively). CONCLUSIONS: The present study showed a strong positive correlation between serum ferritin and levels of FGF23 and 1,25(OH)2D3. We hypothesized that ferritin could have a stimulatory effect on the production of 1,25(OH)2D3. Moreover, a rise in FGF23 in patients with thalassemia, might be either associated with the stimulating effect of PTH and 1,25(OH)2D3, or directly related to the stimulating effect of ferritin. BioMed Central 2020-11-16 /pmc/articles/PMC7667728/ /pubmed/33198660 http://dx.doi.org/10.1186/s12882-020-02101-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Saki, Forough
Salehifar, Azita
Kassaee, Seyed Reza
Omrani, Gholamhossein Ranjbar
Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study
title Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study
title_full Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study
title_fullStr Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study
title_full_unstemmed Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study
title_short Association of vitamin D and FGF23 with serum ferritin in hypoparathyroid thalassemia: a case control study
title_sort association of vitamin d and fgf23 with serum ferritin in hypoparathyroid thalassemia: a case control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667728/
https://www.ncbi.nlm.nih.gov/pubmed/33198660
http://dx.doi.org/10.1186/s12882-020-02101-3
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