TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages

BACKGROUND: TREM2 is a microglial cell surface receptor, with risk mutations linked to Alzheimer’s disease (AD), including R47H. TREM2 signalling via SYK aids phagocytosis, chemotaxis, survival, and changes to microglial activation state. In AD mouse models, knockout (KO) of TREM2 impairs microglial...

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Detalles Bibliográficos
Autores principales: Hall-Roberts, Hazel, Agarwal, Devika, Obst, Juliane, Smith, Thomas B., Monzón-Sandoval, Jimena, Di Daniel, Elena, Webber, Caleb, James, William S., Mead, Emma, Davis, John B., Cowley, Sally A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667762/
https://www.ncbi.nlm.nih.gov/pubmed/33198789
http://dx.doi.org/10.1186/s13195-020-00709-z

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