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Brooke-Spiegler Syndrome With Cervical Spine Lesion
Brooke-Spiegler syndrome (BSS) is a rare hereditary autosomal dominant disorder with variable phenotypic expressivity that results in a variety of benign cutaneous face, scalp, and neck tumors with a histology profile of cylindroma, spiradenoma and trichoepithelioma. Reports of lymph node and distan...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667987/ https://www.ncbi.nlm.nih.gov/pubmed/33209538 http://dx.doi.org/10.7759/cureus.10982 |
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author | Vasenina, Valentina Cibull, Thomas Stadlan, Noam |
author_facet | Vasenina, Valentina Cibull, Thomas Stadlan, Noam |
author_sort | Vasenina, Valentina |
collection | PubMed |
description | Brooke-Spiegler syndrome (BSS) is a rare hereditary autosomal dominant disorder with variable phenotypic expressivity that results in a variety of benign cutaneous face, scalp, and neck tumors with a histology profile of cylindroma, spiradenoma and trichoepithelioma. Reports of lymph node and distant metastasis are scarce. We present the first case of Brooke-Spiegler syndrome with metastasis to the cervical spine. An 86-year-old female with Brooke-Spiegler syndrome presented to the clinic with a finding of cervical spine lesion involving vertebral body, prevertebral, paraspinal, foraminal, and epidural spaces. The histopathology of the lesion showed benign cylindroma. Considering the location of the lesion and local invasion of neural structures, the malignant transformation of existing tumors could not be excluded. Brooke-Spiegler syndrome rarely presents with malignant transformation and distant metastatic spread. It is important to be aware of these rare cases while monitoring the disease and addressing clinical symptoms. This is to our knowledge the first case of metastatic spread of the cylindroma to the cervical spine resulting in local bone destruction and neural elements compromise. Physicians should be aware of this rare possibility. |
format | Online Article Text |
id | pubmed-7667987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-76679872020-11-17 Brooke-Spiegler Syndrome With Cervical Spine Lesion Vasenina, Valentina Cibull, Thomas Stadlan, Noam Cureus Dermatology Brooke-Spiegler syndrome (BSS) is a rare hereditary autosomal dominant disorder with variable phenotypic expressivity that results in a variety of benign cutaneous face, scalp, and neck tumors with a histology profile of cylindroma, spiradenoma and trichoepithelioma. Reports of lymph node and distant metastasis are scarce. We present the first case of Brooke-Spiegler syndrome with metastasis to the cervical spine. An 86-year-old female with Brooke-Spiegler syndrome presented to the clinic with a finding of cervical spine lesion involving vertebral body, prevertebral, paraspinal, foraminal, and epidural spaces. The histopathology of the lesion showed benign cylindroma. Considering the location of the lesion and local invasion of neural structures, the malignant transformation of existing tumors could not be excluded. Brooke-Spiegler syndrome rarely presents with malignant transformation and distant metastatic spread. It is important to be aware of these rare cases while monitoring the disease and addressing clinical symptoms. This is to our knowledge the first case of metastatic spread of the cylindroma to the cervical spine resulting in local bone destruction and neural elements compromise. Physicians should be aware of this rare possibility. Cureus 2020-10-16 /pmc/articles/PMC7667987/ /pubmed/33209538 http://dx.doi.org/10.7759/cureus.10982 Text en Copyright © 2020, Vasenina et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Dermatology Vasenina, Valentina Cibull, Thomas Stadlan, Noam Brooke-Spiegler Syndrome With Cervical Spine Lesion |
title | Brooke-Spiegler Syndrome With Cervical Spine Lesion |
title_full | Brooke-Spiegler Syndrome With Cervical Spine Lesion |
title_fullStr | Brooke-Spiegler Syndrome With Cervical Spine Lesion |
title_full_unstemmed | Brooke-Spiegler Syndrome With Cervical Spine Lesion |
title_short | Brooke-Spiegler Syndrome With Cervical Spine Lesion |
title_sort | brooke-spiegler syndrome with cervical spine lesion |
topic | Dermatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7667987/ https://www.ncbi.nlm.nih.gov/pubmed/33209538 http://dx.doi.org/10.7759/cureus.10982 |
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