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USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L–SMAD pathway
An imbalance in cellular homeostasis occurring as a result of protein misfolding and aggregation contributes to the pathogeneses of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Here, we report the identification of a ubiquitin-specific protease, USP7, as a regulatory sw...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668097/ https://www.ncbi.nlm.nih.gov/pubmed/33106424 http://dx.doi.org/10.1073/pnas.2014349117 |