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Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates
The orbitofrontal cortex (OFC) is a key brain region involved in complex cognitive functions such as reward processing and decision making. Neuroimaging studies have reported unilateral OFC response to reward-related variables; however, those studies rarely discussed this observation. Nevertheless,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668182/ https://www.ncbi.nlm.nih.gov/pubmed/33122437 http://dx.doi.org/10.1073/pnas.2000759117 |
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author | Lopez-Persem, Alizée Roumazeilles, Léa Folloni, Davide Marche, Kévin Fouragnan, Elsa F. Khalighinejad, Nima Rushworth, Matthew F. S. Sallet, Jérôme |
author_facet | Lopez-Persem, Alizée Roumazeilles, Léa Folloni, Davide Marche, Kévin Fouragnan, Elsa F. Khalighinejad, Nima Rushworth, Matthew F. S. Sallet, Jérôme |
author_sort | Lopez-Persem, Alizée |
collection | PubMed |
description | The orbitofrontal cortex (OFC) is a key brain region involved in complex cognitive functions such as reward processing and decision making. Neuroimaging studies have reported unilateral OFC response to reward-related variables; however, those studies rarely discussed this observation. Nevertheless, some lesion studies suggest that the left and right OFC contribute differently to cognitive processes. We hypothesized that the OFC asymmetrical response to reward could reflect underlying hemispherical difference in OFC functional connectivity. Using resting-state and reward-related functional MRI data from humans and from rhesus macaques, we first identified an asymmetrical response of the lateral OFC to reward in both species. Crucially, the subregion showing the highest reward-related asymmetry (RRA) overlapped with the region showing the highest functional connectivity asymmetry (FCA). Furthermore, the two types of asymmetries were found to be significantly correlated across individuals. In both species, the right lateral OFC was more connected to the default mode network compared to the left lateral OFC. Altogether, our results suggest a functional specialization of the left and right lateral OFC in primates. |
format | Online Article Text |
id | pubmed-7668182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | National Academy of Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-76681822020-11-27 Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates Lopez-Persem, Alizée Roumazeilles, Léa Folloni, Davide Marche, Kévin Fouragnan, Elsa F. Khalighinejad, Nima Rushworth, Matthew F. S. Sallet, Jérôme Proc Natl Acad Sci U S A Biological Sciences The orbitofrontal cortex (OFC) is a key brain region involved in complex cognitive functions such as reward processing and decision making. Neuroimaging studies have reported unilateral OFC response to reward-related variables; however, those studies rarely discussed this observation. Nevertheless, some lesion studies suggest that the left and right OFC contribute differently to cognitive processes. We hypothesized that the OFC asymmetrical response to reward could reflect underlying hemispherical difference in OFC functional connectivity. Using resting-state and reward-related functional MRI data from humans and from rhesus macaques, we first identified an asymmetrical response of the lateral OFC to reward in both species. Crucially, the subregion showing the highest reward-related asymmetry (RRA) overlapped with the region showing the highest functional connectivity asymmetry (FCA). Furthermore, the two types of asymmetries were found to be significantly correlated across individuals. In both species, the right lateral OFC was more connected to the default mode network compared to the left lateral OFC. Altogether, our results suggest a functional specialization of the left and right lateral OFC in primates. National Academy of Sciences 2020-11-10 2020-10-29 /pmc/articles/PMC7668182/ /pubmed/33122437 http://dx.doi.org/10.1073/pnas.2000759117 Text en Copyright © 2020 the Author(s). Published by PNAS. http://creativecommons.org/licenses/by/4.0/ https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Biological Sciences Lopez-Persem, Alizée Roumazeilles, Léa Folloni, Davide Marche, Kévin Fouragnan, Elsa F. Khalighinejad, Nima Rushworth, Matthew F. S. Sallet, Jérôme Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates |
title | Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates |
title_full | Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates |
title_fullStr | Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates |
title_full_unstemmed | Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates |
title_short | Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates |
title_sort | differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates |
topic | Biological Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668182/ https://www.ncbi.nlm.nih.gov/pubmed/33122437 http://dx.doi.org/10.1073/pnas.2000759117 |
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