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Law of mass action and saturation in SIR model with application to Coronavirus modelling

When using SIR and related models, it is common to assume that the infection rate is proportional to the product of susceptible and infected individuals. While this assumption works at the onset of the outbreak, the infection force saturates as the outbreak progresses, even in the absence of any int...

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Autores principales: Kolokolnikov, Theodore, Iron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668220/
https://www.ncbi.nlm.nih.gov/pubmed/33225113
http://dx.doi.org/10.1016/j.idm.2020.11.002
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author Kolokolnikov, Theodore
Iron, David
author_facet Kolokolnikov, Theodore
Iron, David
author_sort Kolokolnikov, Theodore
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description When using SIR and related models, it is common to assume that the infection rate is proportional to the product of susceptible and infected individuals. While this assumption works at the onset of the outbreak, the infection force saturates as the outbreak progresses, even in the absence of any interventions. We use a simple agent–based model to illustrate this saturation effect. Its continuum limit leads a modified SIR model with exponential saturation. The derivation is based on first principles incorporating the spread radius and population density. We use the data for coronavirus outbreak for the period from March to June, to show that using SIR model with saturation is sufficient to capture the disease dynamics for many jurstictions, including the overall world-wide disease curve progression. Our model suggests the R(0) value of above 8 at the onset of infection, but with infection quickly “flattening out”, leading to a long-term sustained sub-exponential spread.
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spelling pubmed-76682202020-11-16 Law of mass action and saturation in SIR model with application to Coronavirus modelling Kolokolnikov, Theodore Iron, David Infect Dis Model Special issue on Modelling and Forecasting the 2019 Novel Coronavirus (2019-nCoV) Transmission; Edited by Prof. Carlos Castillo-Chavez, Prof. Gerardo Chowell-Puente, Prof. Ping Yan, Prof. Jianhong Wu When using SIR and related models, it is common to assume that the infection rate is proportional to the product of susceptible and infected individuals. While this assumption works at the onset of the outbreak, the infection force saturates as the outbreak progresses, even in the absence of any interventions. We use a simple agent–based model to illustrate this saturation effect. Its continuum limit leads a modified SIR model with exponential saturation. The derivation is based on first principles incorporating the spread radius and population density. We use the data for coronavirus outbreak for the period from March to June, to show that using SIR model with saturation is sufficient to capture the disease dynamics for many jurstictions, including the overall world-wide disease curve progression. Our model suggests the R(0) value of above 8 at the onset of infection, but with infection quickly “flattening out”, leading to a long-term sustained sub-exponential spread. KeAi Publishing 2020-11-16 /pmc/articles/PMC7668220/ /pubmed/33225113 http://dx.doi.org/10.1016/j.idm.2020.11.002 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Special issue on Modelling and Forecasting the 2019 Novel Coronavirus (2019-nCoV) Transmission; Edited by Prof. Carlos Castillo-Chavez, Prof. Gerardo Chowell-Puente, Prof. Ping Yan, Prof. Jianhong Wu
Kolokolnikov, Theodore
Iron, David
Law of mass action and saturation in SIR model with application to Coronavirus modelling
title Law of mass action and saturation in SIR model with application to Coronavirus modelling
title_full Law of mass action and saturation in SIR model with application to Coronavirus modelling
title_fullStr Law of mass action and saturation in SIR model with application to Coronavirus modelling
title_full_unstemmed Law of mass action and saturation in SIR model with application to Coronavirus modelling
title_short Law of mass action and saturation in SIR model with application to Coronavirus modelling
title_sort law of mass action and saturation in sir model with application to coronavirus modelling
topic Special issue on Modelling and Forecasting the 2019 Novel Coronavirus (2019-nCoV) Transmission; Edited by Prof. Carlos Castillo-Chavez, Prof. Gerardo Chowell-Puente, Prof. Ping Yan, Prof. Jianhong Wu
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668220/
https://www.ncbi.nlm.nih.gov/pubmed/33225113
http://dx.doi.org/10.1016/j.idm.2020.11.002
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