Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents

We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed tha...

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Detalles Bibliográficos
Autores principales: Alshammari, Mohammed B., Ramadan, Mohamed, Aly, Ashraf A., El-Sheref, Essmat M., Bakht, Md Afroz, Ibrahim, Mahmoud A.A., Shawky, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668221/
https://www.ncbi.nlm.nih.gov/pubmed/33223566
http://dx.doi.org/10.1016/j.molstruc.2020.129649
Descripción
Sumario:We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M(pro)) comparable toRemdesivir.

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