Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents

We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed tha...

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Autores principales: Alshammari, Mohammed B., Ramadan, Mohamed, Aly, Ashraf A., El-Sheref, Essmat M., Bakht, Md Afroz, Ibrahim, Mahmoud A.A., Shawky, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668221/
https://www.ncbi.nlm.nih.gov/pubmed/33223566
http://dx.doi.org/10.1016/j.molstruc.2020.129649
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author Alshammari, Mohammed B.
Ramadan, Mohamed
Aly, Ashraf A.
El-Sheref, Essmat M.
Bakht, Md Afroz
Ibrahim, Mahmoud A.A.
Shawky, Ahmed M.
author_facet Alshammari, Mohammed B.
Ramadan, Mohamed
Aly, Ashraf A.
El-Sheref, Essmat M.
Bakht, Md Afroz
Ibrahim, Mahmoud A.A.
Shawky, Ahmed M.
author_sort Alshammari, Mohammed B.
collection PubMed
description We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M(pro)) comparable toRemdesivir.
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spelling pubmed-76682212020-11-16 Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents Alshammari, Mohammed B. Ramadan, Mohamed Aly, Ashraf A. El-Sheref, Essmat M. Bakht, Md Afroz Ibrahim, Mahmoud A.A. Shawky, Ahmed M. J Mol Struct Article We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M(pro)) comparable toRemdesivir. Elsevier B.V. 2021-04-15 2020-11-16 /pmc/articles/PMC7668221/ /pubmed/33223566 http://dx.doi.org/10.1016/j.molstruc.2020.129649 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Alshammari, Mohammed B.
Ramadan, Mohamed
Aly, Ashraf A.
El-Sheref, Essmat M.
Bakht, Md Afroz
Ibrahim, Mahmoud A.A.
Shawky, Ahmed M.
Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents
title Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents
title_full Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents
title_fullStr Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents
title_full_unstemmed Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents
title_short Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents
title_sort synthesis of potentially new schiff bases of n-substituted-2-quinolonylacetohydrazides as anti-covid-19 agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668221/
https://www.ncbi.nlm.nih.gov/pubmed/33223566
http://dx.doi.org/10.1016/j.molstruc.2020.129649
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