In vitro studies provide insight into effects of Dicer-2 helicase mutations in Drosophila melanogaster

In vitro, Drosophila melanogaster Dicer-2 (Dcr-2) uses its helicase domain to initiate processing of dsRNA with blunt (BLT) termini, and its Platform•PAZ domain to initiate processing of dsRNA with 3′ overhangs (ovrs). To understand the relationship of these in vitro observations to roles of Dcr-2 i...

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Detalles Bibliográficos
Autores principales: Donelick, Helen M., Talide, Loïc, Bellet, Matthieu, Aruscavage, P. Joseph, Lauret, Emilie, Aguiar, Eric R.G.R., Marques, Joao T., Meignin, Carine, Bass, Brenda L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7668257/
https://www.ncbi.nlm.nih.gov/pubmed/32843367
http://dx.doi.org/10.1261/rna.077289.120

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